| ○種別 (必須): | □ | 総説·解説
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 齊藤 達哉
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Akira Shizuo (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Regulation of inflammasomes by autophagy. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Inflammasomes detect pathogen-associated molecular patterns to induce inflammatory innate immune responses and play a key role in host defense against infectious agents. However, inflammasomes are often wrongly activated by metabolites, amyloids, and environmental irritants. This induces massive inflammation, causing severe tissue damage, and results in the development of inflammatory diseases. Hence cellular machineries regulating both "activation" and "inactivation" of inflammasomes are definitely important. Recent studies have shown that autophagy, an intracellular degradation system associated with maintenance of cellular homeostasis, plays a key role in inflammasome inactivation. Notably, autophagy deficiency caused by gene mutation disrupts organelle elimination and thus induces aberrant activation of inflammasomes, leading to severe tissue damage. Here we review recent findings regarding the involvement of autophagy in the regulation of inflammasome activation and development of inflammatory disorders. (日)
| [継承] |
| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Allergy and Clinical Immunology (American Academy of Allergy/American Academy of Allergy and Immunology/American Academy of Allergy Asthma and Immunology)
(pISSN: 0091-6749, eISSN: 1097-6825)
| ○ISSN (任意): | □ | 1097-6825
ISSN: 0091-6749
(pISSN: 0091-6749, eISSN: 1097-6825) Title: The Journal of allergy and clinical immunologyTitle(ISO): J Allergy Clin ImmunolPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 138
| [継承] |
| ○号 (必須): | □ | 1
| [継承] |
| ○頁 (必須): | □ | 28 36
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 24日 (平成 28年 5月 24日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jaci.2016.05.009 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 27373323 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○Scopus (任意): |
| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
| [継承] |
| 2. | (英) PublicationType: Review (日)
| [継承] |