| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Bragiel Aneta (日) Bragiel Aneta (読) アネタ ブラジエル
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Wang Di (日) 王 由頁 (読) ワン ディ
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| ○学籍番号 (推奨): |
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| 3. | (英) Pieczonka Tonasz (日) Pieczonka Tomasz (読) ペクゾンカ トーマス
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Shono Masayuki (日) 庄野 正行 (読) しょうの まさゆき
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 石川 康子
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Mechanisms underlying activation of α1-adrenergic receptor-induced trafficking of AQP5 in rat parotid acinar cells under isotonic or hypototonic conditions (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Defective cellular trafficking of AQP5 to the apical plasma membrane (APM) in salivary glands is associated with the loss of salivary fluid secretion. To examine mechanisms of 1A1-adrenoceptor (AR)-induced trafficking of AQP5, immunoconfocal microscopy and Western blot analysis were used to analyze AQP5 localization in parotid tissues stimulated with phenylephrine under different osmolality. Phenylephrine-induced trafficking of AQP5 to the APM and lateral plasma membrane (LPM) was mediated via the 1A-AR subtype, but not the 1B- and 1D-AR subtypes, with a subsequent rise in cytosolic calcium ([Ca2+]i).. Phenylephrine-induced trafficking of AQP5 was inhibited by ODQ and KT5823, indicating the involvement of the NO/cGC/PKG signaling pathway. Under isotonic conditions, phenylephrine-induced trafficking was inhibited by La3+, implying the participation of store-operated Ca2+ channel. Under hypotonic conditions, phenylephrine-induced trafficking of AQP5 to the APM was higher than that under isotonic conditions. Under non-stimulated conditions, hypotonicity-induced trafficking of AQP5 to the APM was inhibited by ruthenium red, and La3+, suggesting the involvement of extracellular Ca2+ entry. Thus, 1A-AR activation induced the trafficking of AQP5 to the APM and LPM via the Ca2+/cGMP/PKG signaling pathway, which is associated with store-operated Ca2+ entry. (日)
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| ○キーワード (推奨): | 1. | (英) Acinar cells (日) (読)
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| 2. | (英) Aquaporin 5 (日) (読)
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| 3. | (英) Apical Plasma membrane (日) (読)
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| 4. | (英) Nuclei (日) (読)
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| 5. | (英) Trafficking (日) (読)
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| 6. | (英) Parotid glands (日) (読)
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| 7. | (英) Diabetes Mellitus, Experimental (日) (読)
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| 8. | (英) Down-Regulation (日) (読)
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| 9. | (英) Hypoglycemic Agents (日) (読)
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| 10. | 免疫組織化学 (immunohistochemistry)
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| 11. | インスリン (insulin)
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| 12. | 男性 (male)
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| 13. | (英) Membrane Proteins (日) (読)
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| 14. | (英) Muscarinic Agonists (日) (読)
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| 15. | 一酸化窒素 (nitric oxide)
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| 16. | (英) Parotid Gland (日) (読)
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| 17. | (英) Protein Transport (日) (読)
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| 18. | (英) Quinuclidines (日) (読)
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| 19. | (英) Rats (日) (読)
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| 20. | (英) Rats, Wistar (日) (読)
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| 21. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 22. | (英) Thiophenes (日) (読)
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| 23. | (英) Time Factors (日) (読)
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| 24. | (英) Xerostomia (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 17
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1022 1041
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 28日 (平成 28年 6月 28日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms17071022 (→Scopusで検索)
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| ○PMID (任意): | □ | 27367668 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 112395
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3390/ijms17071022 (日)
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| 2. | (英) Article.ELocationID: E1022 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) OtherID: PMC4964398 (日)
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| 5. | (英) KeywordList.Keyword: aquaporin-5 (日)
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| 6. | (英) KeywordList.Keyword: calcium (日)
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| 7. | (英) KeywordList.Keyword: hypotonicity (日)
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| 8. | (英) KeywordList.Keyword: protein G kinase (日)
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| 9. | (英) KeywordList.Keyword: α1A-adrenoceptor (日)
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| 10. | (英) KeywordList.Keyword: α1B-adrenoceptor (日)
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| 11. | (英) KeywordList.Keyword: α1D-adrenoceptor (日)
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