| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Park Jae-Hyun (日) (読)
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| 2. | (英) Jang Miran (日) (読)
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| 3. | (英) Tarhan Yunus Emre (日) (読)
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| 4. | 片桐 豊雅
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| 5. | (英) Sasa Mitsunori (日) (読)
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| 6. | (英) Miyoshi Yasuo (日) (読)
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| 7. | (英) Kalari Krishna R (日) (読)
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| 8. | (英) Suman Vera J (日) (読)
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| 9. | (英) Weinshilboum Richard (日) (読)
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| 10. | (英) Wang Liewei (日) (読)
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| 11. | (英) Boughey Judy C (日) (読)
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| 12. | (英) Goetz Matthew P (日) (読)
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| 13. | (英) Nakamura Yusuke (日) (読)
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| ○題名 (必須): | □ | (英) Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. (日)
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| ○要約 (任意): | □ | (英) The immune microenvironment of tumor plays a critical role in therapeutic responses to chemotherapy. Cancer tissues are composed of a complex network between antitumor and pro-tumor immune cells and molecules; therefore a comprehensive analysis of the tumor immune condition is imperative for better understanding of the roles of the immune microenvironment in anticancer treatment response. In this study, we performed T cell receptor (TCR) repertoire analysis of tumor infiltrating T cells (TILs) in cancer tissues of pre- and post-neoadjuvant chemotherapy (NAC) from 19 breast cancer patients; five cases showed CR (complete response), ten showed PR (partial response), and four showed SD/PD (stable disease/progressive disease) to the treatment. From the TCR sequencing results, we calculated the diversity index of the TCRβ chain and found that clonal expansion of TILs could be detected in patients who showed CR or PR to NAC. Noteworthy, the diversity of TCR was further reduced in the post-NAC tumors of CR patients. Our quantitative RT-PCR also showed that expression ratio of CD8/Foxp3 was significantly elevated in the post-NAC tumors of CR cases (p=0.0032), indicating that antitumor T cells were activated and enriched in these tumors. Collectively, our findings suggest that the clonal expansion of antitumor T cells may be a critical factor associated with response to chemotherapy and that their TCR sequences might be applicable for the development of TCR-engineered T cells treatment for individual breast cancer patients when their tumors relapse. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)
| ○ISSN (任意): | □ | 1791-2423
ISSN: 1019-6439
(pISSN: 1019-6439, eISSN: 1791-2423) Title: International journal of oncologyTitle(ISO): Int J OncolPublisher: Spandidos Publications (NLM Catalog)
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| ○巻 (必須): | □ | 49
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 471 478
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 27日 (平成 28年 5月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/ijo.2016.3540 (→Scopusで検索)
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| ○PMID (任意): | □ | 27278091 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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