| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.工学部.化学応用工学科.物質機能化学講座 (〜2023年3月31日)
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| ○著者 (必須): | 1. | (英) Li Jiang (日) (読)
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| 2. | コインカー パンカジ ([徳島大学.大学院社会産業理工学研究部]/[徳島大学.理工学部.理工学科.光システムコース.光機能材料講座]/[徳島大学.大学院理工学研究部]/[徳島大学.工学部.光応用工学科.光機能材料講座]/[徳島大学.先端技術科学教育部.システム創生工学専攻.光システム工学コース.光機能材料工学講座])
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| 3. | (英) Fuchiwaki Yusuke (日) (読)
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| 4. | 安澤 幹人 ([徳島大学.大学院社会産業理工学研究部])
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| ○題名 (必須): | □ | (英) A fine pointed glucose oxidase immobilized electrode for low-invasive amperometric glucose monitoring (日)
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| ○要約 (任意): | □ | (英) A low invasive type glucose sensor, which has a sensing region at the tip of a fine pointed electrode, was developed for continuous glucose monitoring. Platinum-iridium alloy electrode with a surface area of 0.045 mm2 was settled at the middle of pointed PEEK (Polyetheretherketone) tubing and was employed as sensing electrode. Electrodeposition of glucose oxidase in the presence of surfactant, Triton X-100, was performed for high-density enzyme immobilization followed by the electropolymerization of o-phenylenediamine for the formation of functional entrapping and permselective polymer membrane. Ag/AgCl film was coated on the surface of PEEK tubing as reference electrode. Amperometric responses of the prepared sensors to glucose were measured at a potential of 0.60 V (vs. Ag/AgCl). The prepared electrode showed the sensitivity of 2.55 mA/cm2 mM with high linearity of 0.9986, within the glucose concentration range up to 21 mM. The detection limit (S/N=3) was determined to be 0.11 mM. The glucose sensor properties were evaluated in phosphate buffer solution and in vivo monitoring by the implantation of the sensors in rabbit, while conventional needle type sensors as a reference were used. The results showed that change in output current of the proposed sensor fluctuated similar with one in output current of the conventional needle type sensors, which was also in similar accordance with actual blood sugar level measured by commercially glucose meter. One-point calibration method was used to calibrate the sensor output current. (日)
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| ○キーワード (推奨): | 1. | (英) Continuous glucose monitoring (日) (読)
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| 2. | インビボ測定 (in vivo measurement)
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| 3. | (英) Low-invasive device (日) (読)
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| 4. | (英) Glucose oxidase (日) (読)
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| ○発行所 (推奨): | □ | Elsevier (->組織[Elsevier Science])
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| ○誌名 (必須): | □ | Biosensors and Bioelectronics ([Elsevier])
(pISSN: 0956-5663, eISSN: 1873-4235)
| ○ISSN (任意): | □ | 0956-5663
ISSN: 0956-5663
(pISSN: 0956-5663, eISSN: 1873-4235) Title: Biosensors & bioelectronicsTitle(ISO): Biosens BioelectronPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 86
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 90 94
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| ○年月日 (必須): | □ | 西暦 2016年 12月 15日 (平成 28年 12月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bios.2016.06.037 (→Scopusで検索)
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| ○WOS : | □ | 000384853300014
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| ○Scopus (任意): | 1. | 2-s2.0-84975493829
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