| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yoshino Y (日) (読)
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| 2. | (英) Kawabe K (日) (読)
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| 3. | (英) Mori T (日) (読)
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| 4. | (英) Mori Y (日) (読)
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| 5. | (英) Yamazaki K (日) (読)
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| 6. | 沼田 周助 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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| 7. | (英) Nakata S (日) (読)
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| 8. | (英) Yoshida T (日) (読)
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| 9. | (英) Iga JI (日) (読)
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| 10. | 大森 哲郎
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| 11. | (英) Ueno SI (日) (読)
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| ○題名 (必須): | □ | (英) Low methylation rates of dopamine receptor D2 gene promoter sites in Japanese schizophrenia subjects. (日)
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| ○要約 (任意): | □ | (英) According to the dopamine hypothesis, several studies on the gene for the dopamine receptor D2 (DRD2) have been conducted. However, no trait biomarkers on DRD2 are available. We examined whether the methylation rates in the upstream region of DRD2 in leukocytes are different in schizophrenia (SCZ) subjects compared to control subjects. We selected seven CpG sites in the upstream region of DRD2 that may theoretically bind major transcription factors. The methylation rates in these regions of 50 medicated and 18 drug-naïve SCZ subjects were compared with those of age-matched control subjects. The methylation rates were significantly lower in medicated (CpG2, P < 0.0001; CpG4, P = 0.013; CpG7, P < 0.0001; and average: 12.9 ± 1.8 vs. 14.1 ± 2.2, P = 0.005) and drug-naïve SCZ subjects (CpG1, P = 0.006; CpG2, P = 0.001; CpG3, P = 0.001; CpG5, P = 0.02; CpG6, P = 0.015; CpG7, P = 0.027; and average: 9.86 ± 0.9 vs. 11.2 ± 1.3, P = 0.002). We confirmed low methylation rates in the upstream region of DRD2 in both medicated and drug-naïve SCZ subjects. Low methylation rates of DRD2 in leukocytes may be a trait biomarker for SCZ. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | The World Journal of Biological Psychiatry ([World Federation of Societies of Biological Psychiatry])
(pISSN: 1562-2975, eISSN: 1814-1412)
| ○ISSN (任意): | □ | 1814-1412
ISSN: 1562-2975
(pISSN: 1562-2975, eISSN: 1814-1412) Title: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological PsychiatryTitle(ISO): World J Biol PsychiatryPublisher: Taylor & Francis (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 17
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 449 456
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 7月 6日 (平成 28年 7月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1080/15622975.2016.1197424 (→Scopusで検索)
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| ○PMID (任意): | □ | 27269479 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000383408000005
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| ○Scopus (任意): | 1. | 2-s2.0-84978998399
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1080/15622975.2016.1197424 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Biomarker (日)
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| 4. | (英) KeywordList.Keyword: dopamine receptor D2 gene (日)
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| 5. | (英) KeywordList.Keyword: methylation (日)
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| 6. | (英) KeywordList.Keyword: pyrosequencer (日)
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| 7. | (英) KeywordList.Keyword: schizophrenia (日)
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