| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○著者 (必須): | 1. | 梅原 英裕 ([徳島大学.キャンパスライフ健康支援センター])
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 沼田 周助 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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| 3. | 田嶋 敦
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| 4. | (英) Nishi Akira (日) 西 晃 (読) にし あきら
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 中瀧 理仁 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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| 6. | 井本 逸勢
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| 7. | 住谷 さつき
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| 8. | 大森 哲郎
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| ○題名 (必須): | □ | (英) Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder. (日)
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| ○要約 (任意): | □ | (英) Selective serotonin reuptake inhibitors (SSRI) are established first-line pharmacological treatments for obsessive-compulsive disorder (OCD), while antipsychotics are used as an augmentation strategy for SSRI in OCD patients who have either no response or a partial response to SSRI treatment. The goal of the present study was to identify genetic variants and pathways that are associated with the long-term clinical response of OCD patients to SSRI or SSRI with antipsychotics. We first performed a genome-wide association study of 96 OCD patients to examine genetic variants contributing to the response to SSRI or SSRI with antipsychotics. Subsequently, we conducted pathway-based analyses by using Improved Gene Set Enrichment Analysis for Genome-wide Association Study (i-GSEA4GWAS) to examine the combined effects of genetic variants on the clinical response in OCD. While we failed to detect specific genetic variants associated with clinical responses to SSRI or to SSRI with an atypical antipsychotic at genome-wide levels of significance, we identified 8 enriched pathways for the SSRI treatment response and 5 enriched pathways for the treatment response to SSRI with an antipsychotic medication. Notably, the calcium signaling pathway was identified in both treatment responses. Our results provide novel insight into the molecular mechanisms underlying the variability in clinical response to SSRI and SSRI with antipsychotics in OCD patients. (日)
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| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | e0157232. e0157232.
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 9日 (平成 28年 6月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0157232 (→Scopusで検索)
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| ○PMID (任意): | □ | 27281126 (→Scopusで検索)
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| ○WOS : | □ | 000377563000111
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| ○Scopus (任意): | 1. | 2-s2.0-84975507364
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| ○機関リポジトリ : | □ | 112308
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0157232 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4900663 (日)
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