| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 南川 丈夫
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| 2. | (英) Matsuo Hisataka (日) (読)
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| 3. | (英) Kato Yoshiyuki (日) (読)
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| 4. | (英) Harada Yoshinori (日) (読)
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| 5. | (英) Otsuji Eigo (日) (読)
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| 6. | (英) Yanagisawa Akio (日) (読)
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| 7. | (英) Tanaka Hideo (日) (読)
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| 8. | (英) Takamatsu Tetsuro (日) (読)
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| ○題名 (必須): | □ | (英) Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions. (日)
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| ○要約 (任意): | □ | (英) 5-aminolevulinic acid (5-ALA)-based fluorescence diagnosis is now clinically applied for accurate and ultrarapid diagnosis of malignant lesions such as lymph node metastasis during surgery. 5-ALA-based diagnosis evaluates fluorescence intensity of a fluorescent metabolite of 5-ALA, protoporphyrin IX (PPIX); however, the fluorescence of PPIX is often affected by autofluorescence of tissue chromophores, such as collagen and flavins. In this study, we demonstrated PPIX fluorescence estimation with autofluorescence elimination for 5-ALA-based fluorescence diagnosis of malignant lesions by simplified and optimized multispectral imaging. We computationally optimized observation wavelength regions for the estimation of PPIX fluorescence in terms of minimizing prediction error of PPIX fluorescence intensity in the presence of typical chromophores, collagen and flavins. By using the fluorescence intensities of the optimized wavelength regions, we verified quantitative detection of PPIX fluorescence by using chemical mixtures of PPIX, flavins, and collagen. Furthermore, we demonstrated detection capability by using metastatic and non-metastatic lymph nodes of colorectal cancer patients. These results suggest the potential and usefulness of the background-free estimation method of PPIX fluorescence for 5-ALA-based fluorescence diagnosis of malignant lesions, and we expect this method to be beneficial for intraoperative and rapid cancer diagnosis. (日)
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| ○誌名 (必須): | □ | Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)
| ○ISSN (任意): | □ | 2045-2322
ISSN: 2045-2322
(eISSN: 2045-2322) Title: Scientific reportsTitle(ISO): Sci RepPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 6
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 25530 25530
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| ○年月日 (必須): | □ | 西暦 2016年 5月 5日 (平成 28年 5月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/srep25530 (→Scopusで検索)
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| ○PMID (任意): | □ | 27149301 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84966700309
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| ○機関リポジトリ : | □ | 112316
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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