| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 島袋 充生
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| 2. | (英) Okawa C (日) (読)
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| 3. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| 4. | (英) Yanagi S (日) (読)
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| 5. | (英) Uematsu E (日) (読)
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| 6. | (英) Sugasawa N (日) (読)
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| 7. | 黒部 裕嗣
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| 8. | (英) Hirata Y (日) (読)
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| 9. | (英) Kim-Kaneyama JR (日) (読)
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| 10. | (英) Lei XF (日) (読)
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| 11. | (英) Takao S (日) (読)
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| 12. | (英) Tanaka Y (日) (読)
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| 13. | 福田 大受
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| 14. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])
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| 15. | 添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 16. | 北川 哲也
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| 17. | (英) Masuzaki H (日) (読)
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| 18. | (英) Sato M (日) (読)
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| 19. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| ○題名 (必須): | □ | (英) The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: A study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe. (日)
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| ○要約 (任意): | □ | (英) Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD+Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD+E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4β-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4β-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 4β-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function. (日)
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| ○キーワード (推奨): | 1. | (英) Cardiac function (日) (読)
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| 2. | (英) Cardiac hypertrophy (日) (読)
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| 3. | (英) Epicardial fat (日) (読)
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| 4. | (英) Obesity (日) (読)
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| 5. | (英) Oxycholesterol (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Nutritional Biochemistry ([Elsevier])
(pISSN: 0955-2863, eISSN: 1873-4847)
| ○ISSN (任意): | □ | 1873-4847
ISSN: 0955-2863
(pISSN: 0955-2863, eISSN: 1873-4847) Title: The Journal of nutritional biochemistryTitle(ISO): J Nutr BiochemPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 35
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 66 73
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 31日 (平成 28年 5月 31日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jnutbio.2016.05.010 (→Scopusで検索)
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| ○PMID (任意): | □ | 27416363 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0955-2863(16)30109-7 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.jnutbio.2016.05.010 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE (日)
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| 4. | (英) KeywordList.Keyword: Cardiac function (日)
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| 5. | (英) KeywordList.Keyword: Cardiac hypertrophy (日)
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| 6. | (英) KeywordList.Keyword: Epicardial fat (日)
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| 7. | (英) KeywordList.Keyword: Obesity (日)
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| 8. | (英) KeywordList.Keyword: Oxycholesterol (日)
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