| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Miyamoto Yoshihiko (日) (読)
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| 2. | 六車 直樹
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| 3. | 木村 哲夫
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| 4. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 5. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| 6. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 7. | (英) Kohno Seiya (日) (読)
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| 8. | (英) Nakasono Masahiko (日) (読)
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| 9. | (英) Hayashi Hiroshige (日) (読)
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| 10. | 坂東 良美 ([徳島大学.病院.診療科.病理診断科])
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| 11. | 高山 哲治
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| ○題名 (必須): | □ | (英) Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) A 29-year-old female visited a hospital because of increasingly severe lower leg edema. She was diagnosed as having multiple polyps in the stomach and colon by gastroscopy and sigmoidoscopy as well as multiple liver tumors by abdominal CT. She was referred to our hospital for further examination. Total colonoscopy revealed a type 2 tumor in the transverse colon and more than 200 polyps distributed throughout the colorectum. Biopsies of the tumor and polyps showed histological characteristics of adenocarcinoma and tubulovillous adenoma, respectively. Thus, she was diagnosed as having metastatic colon cancer derived from familial adenomatous polyposis (FAP). Laboratory tests showed a marked hypoalbuminemia of 1.1 g/dl. The fecal alpha-1 anti-trypsin test showed abnormal clearance (62.1 ml/day), and scintigraphy using 99mTc-human serum albumin revealed protein loss in the whole colon. Multiple ligation probe amplification analysis of the APC gene identified a germline duplication of exons 11-13. Direct sequencing of the reverse transcription PCR products of APC mRNA revealed a deletion of 25 base pairs and a tandem duplication of exons 11-13. This case was considered to be protein-losing enteropathy resulting from numerous colonic tubulovillous adenomas and advanced colon cancer in a FAP patient with unusual mutational events in APC. (日)
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| ○キーワード (推奨): | 1. | (英) Adenomatous Polyposis Coli (日) (読)
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| 2. | (英) Adult (日) (読)
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| 3. | (英) Colonic Neoplasms (日) (読)
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| 4. | (英) Colonoscopy (日) (読)
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| 5. | (英) DNA Mutational Analysis (日) (読)
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| 6. | (英) Edema (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Gastroscopy (日) (読)
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| 9. | (英) Genes, APC (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Leg (日) (読)
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| 12. | (英) Liver Neoplasms (日) (読)
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| 13. | (英) Mutation (日) (読)
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| 14. | (英) Pedigree (日) (読)
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| 15. | (英) Protein-Losing Enteropathies (日) (読)
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| 16. | (英) Radionuclide Imaging (日) (読)
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| 17. | (英) Tomography, X-Ray Computed (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Clinical Journal of Gastroenterology ([財団法人 日本消化器病学会])
(pISSN: 1865-7257, eISSN: 1865-7265)
| ○ISSN (任意): | □ | 1865-7257
ISSN: 1865-7257
(pISSN: 1865-7257, eISSN: 1865-7265) Title: Clinical journal of gastroenterologyTitle(ISO): Clin J GastroenterolPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 134 139
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 初日 (平成 28年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s12328-016-0650-y (→Scopusで検索)
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| ○PMID (任意): | □ | 27170298 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84966709449
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s12328-016-0650-y (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Case Reports (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: APC gene mutation (日)
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| 5. | (英) KeywordList.Keyword: Leg edema (日)
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| 6. | (英) KeywordList.Keyword: Tubulovillous adenoma (日)
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