| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Akabane Shiori (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Uno Midori (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Tani Naoki (日) (読)
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| 4. | (英) Shimazaki Shunta (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Ebara Natsumi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Kato Hiroki (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 小迫 英尊 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| 8. | (英) Oka Toshihiko (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) PKA regulates PINK1 stability and Parkin recruitment to damaged mitochondria through phosphorylation of MIC60. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) A mitochondrial kinase, PTEN-induced putative kinase 1 (PINK1), selectively recruits the ubiquitin ligase Parkin to damaged mitochondria, which modifies mitochondria by polyubiquitination, leading to mitochondrial autophagy. Here, we report that treatment with an adenylate cyclase agonist or expression of protein kinase A (PKA) impairs Parkin recruitment to damaged mitochondria and decreases PINK1 protein levels. We identified a mitochondrial membrane protein, MIC60 (also known as mitofilin), as a PKA substrate. Mutational and mass spectrometric analyses revealed that the Ser528 residue of MIC60 undergoes PKA-dependent phosphorylation. MIC60 transiently interacts with PINK1, and MIC60 downregulation leads to a reduction in PINK1 and mislocalization of Parkin. Phosphorylation-mimic mutants of MIC60 fail to restore the defect in Parkin recruitment in MIC60-knocked down cells, whereas a phosphorylation-deficient MIC60 mutant facilitates the mitochondrial localization of Parkin. Our findings indicate that PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 and Parkin. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Molecular Cell (Cell Press)
(pISSN: 1097-2765, eISSN: 1097-4164)
| ○ISSN (任意): | □ | 1097-4164
ISSN: 1097-2765
(pISSN: 1097-2765, eISSN: 1097-4164) Title: Molecular cellTitle(ISO): Mol CellPublisher: Cell Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 62
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 371 384
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 5日 (平成 28年 5月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.molcel.2016.03.037 (→Scopusで検索)
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| ○PMID (任意): | □ | 27153535 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000376444700007
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| ○Scopus (任意): | 1. | 2-s2.0-84966667783
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.molcel.2016.03.037 (日)
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| 2. | (英) Article.ELocationID: S1097-2765(16)30050-8 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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