| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 岡田 直人
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| 2. | (英) Hanafusa Takeshi (日) 花房 剛志 (読)
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| 3. | 阿部 真治 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.臨床薬学実務教育学])
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| 4. | 佐藤 智恵美 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.臨床薬学実務教育学])
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| 5. | (英) Nakamura Toshimi (日) 中村 敏己 (読)
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| 6. | 寺岡 和彦
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| 7. | 安倍 正博
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| 8. | 川添 和義
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| 9. | 石澤 啓介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学])
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| ○題名 (必須): | □ | (英) Evaluation of the risk factors associated with high-dose chemotherapyinduced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: Possible usefulness of cryotherapy in dysgeusia prevention (日)
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| ○要約 (任意): | □ | (英) Dysgeusia is one of the sporadic adverse effects induced by chemotherapy, but it remains poorly understood. The aim of this study was to retrospectively identify the risk factors related with dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation (AHSCT). Forty-eight patients with myeloma or lymphoma undergoing AHSCT were enrolled in this study. Data regarding dysgeusia and symptoms were collected by interviews conducted by medical workers. Patient characteristics and unfavorable effects induced by dysgeusia were obtained from medical records and analyzed. Logistic regression analysis was performed to identify the risk factors related with dysgeusia. Of the 48 patients, 20 (42 %) had dysgeusia after AHSCT. The total period of parenteral nutrition (TPN) administration and period of decreased oral intake in the dysgeusia group were statistically longer than those in the non-dysgeusia group. Multivariate analyses revealed that oral mucositis (odds ratio: 30.3; p < 0.01) and the type of chemotherapy prior to AHSCT (odds ratio: 6.56; p < 0.05) were independent risk factors, while oral cryotherapy was the independent suppressive factor of dysgeusia (odds ratio: 0.14; p < 0.05). Our study showed that dysgeusia after AHSCT led to the decrease in oral intake and extended the TPN administration period. Moreover, MEAM or LEED chemotherapy and oral mucositis were independent risk factors for dysgeusia in patients undergoing AHSCT, while oral cryotherapy was an independent suppressive factor for dysgeusia. Therefore, oral cryotherapy should be implemented into the regimen of supportive care management in patients undergoing AHSCT. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Supportive Care in Cancer (Multinational Association of Supportive Care in Cancer)
(pISSN: 0941-4355, eISSN: 1433-7339)
| ○ISSN (任意): | □ | 1433-7339
ISSN: 0941-4355
(pISSN: 0941-4355, eISSN: 1433-7339) Title: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in CancerTitle(ISO): Support Care CancerSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 24
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 3979 3985
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 29日 (平成 28年 4月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00520-016-3244-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 27129837 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00520-016-3244-9 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Autologous hematopoietic stem cell transplantation (日)
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| 4. | (英) KeywordList.Keyword: Dysgeusia (日)
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| 5. | (英) KeywordList.Keyword: Oral cryotherapy (日)
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| 6. | (英) KeywordList.Keyword: Supportive care (日)
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