『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=311902)

EID=311902EID:311902, Map:0, LastModified:2017年12月4日(月) 14:05:07, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[加藤 有介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.加藤 有介 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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[継承]
2.福井 清 ([徳島大学])
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3.鈴木 和男 (帝京大学アジア国際感染症制御研究所)
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題名 (必須): (英) Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Avian influenza H5N1 has shown high mortality rate in human. Non-structural protein 1 (NS1) is a virulence factor of H5N1. Mutation at the 42nd residue within the RNA-binding domain (RBD) of NS1 dramatically changes the degree of pathogenicity of H5N1 in mice. We here studied the impact of this mutation on the function of RBD, and found that RBD with serine at the 42th residue binds double-stranded RNA (dsRNA), whereas that with proline at the 42th residue does not. Analysis of structural models of the RBD proteins with S42 and P42 suggested remarkable difference in the structure of the dsRNA-binding interface, whereas structural analysis by analytical gel filtration and CD measurements did not indicate difference between those RBD proteins. Our results suggest that the single amino acid replacement induces a minor, but global structural change leading to the loss of function of NS1 thereby the change in the degree of pathogenicity.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Protein and Peptide Letters (Bentham Science Publishers)
(pISSN: 0929-8665, eISSN: 1875-5305)

ISSN (任意): 1875-5305
ISSN: 0929-8665 (pISSN: 0929-8665, eISSN: 1875-5305)
Title: Protein and peptide letters
Title(ISO): Protein Pept. Lett.
Publisher: Bentham Science Publishers
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 23 [継承]
(必須): 4 [継承]
(必須): 372 378 [継承]
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年月日 (必須): 西暦 2016年 4月 1日 (平成 28年 4月 1日) [継承]
URL (任意):
DOI (任意): 10.2174/0929866523666160204124406    (→Scopusで検索) [継承]
PMID (任意): 26845765    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000373715300007 [継承]
Scopus (任意): 2-s2.0-84961707855 [継承]
機関リポジトリ : 110030 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yusuke Kato, Kiyoshi Fukui and Kazuo Suzuki : Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1., Protein and Peptide Letters, Vol.23, No.4, 372-378, 2016.
欧文冊子 ● Yusuke Kato, Kiyoshi Fukui and Kazuo Suzuki : Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1., Protein and Peptide Letters, Vol.23, No.4, 372-378, 2016.

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