『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない)) [継承]
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著者 (必須): 1.北岡 和義 ([徳島大学.教養教育院])
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2. (英) Kawata Shiyori (日) 川田 知代 (読) かわた しより
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学籍番号 (推奨): **** [ユーザ]
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3. (英) Yoshida Tomohiro (日) 田 朋広 (読) よしだ ともひろ
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学籍番号 (推奨): **** [ユーザ]
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4. (英) Kadoriku Fumiya (日) 角陸 文哉 (読) かどりく ふみや
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学籍番号 (推奨): **** [ユーザ]
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5.北村 光夫 ([徳島大学.技術支援部])
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題名 (必須): (英) Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line  (日)    [継承]
副題 (任意):
要約 (任意): (英) Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices. In the last several decades, some evidence has shown an association between ELF-MF exposure and depression and/or anxiety in epidemiological and animal studies. The mechanism underlying ELF-MF-induced depression is considered to involve adrenal steroidogenesis, which is triggered by ELF-MF exposure. However, how ELF-MFs stimulate adrenal steroidogenesis is controversial. In the current study, we investigated the effect of ELF-MF exposure on the mouse adrenal cortex-derived Y-1 cell line and the human adrenal cortex-derived H295R cell line to clarify whether the ELF-MF stimulates adrenal steroidogenesis directly. ELF-MF exposure was found to significantly stimulate adrenal steroidogenesis (p < 0.01-0.05) and the expression of adrenal steroid synthetic enzymes (p < 0.05) in Y-1 cells, but the effect was weak in H295R cells. Y-1 cells exposed to an ELF-MF showed significant decreases in phosphodiesterase activity (p < 0.05) and intracellular Ca2+ concentration (p < 0.01) and significant increases in intracellular cyclic adenosine monophosphate (cAMP) concentration (p < 0.001-0.05) and cAMP response element-binding protein phosphorylation (p < 0.05). The increase in cAMP was not inhibited by treatment with NF449, an inhibitor of the Gs alpha subunit of G protein. Our results suggest that ELF-MF exposure stimulates adrenal steroidogenesis via an increase in intracellular cAMP caused by the inhibition of phosphodiesterase activity in Y-1 cells. The same mechanism may trigger the increase in adrenal steroid secretion in mice observed in our previous study.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 11 [継承]
(必須): 4 [継承]
(必須): e0154167 e0154167 [継承]
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年月日 (必須): 西暦 2016年 4月 21日 (平成 28年 4月 21日) [継承]
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DOI (任意): 10.1371/journal.pone.0154167    (→Scopusで検索) [継承]
PMID (任意): 27100201    (→Scopusで検索) [継承]
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WOS (任意): 000374898500159 [継承]
Scopus (任意): 2-s2.0-84964653269 [継承]
機関リポジトリ : 112306 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0154167  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4839720  (日)    [継承]

標準的な表示

和文冊子 ● Kazuyoshi Kitaoka, Shiyori Kawata, Tomohiro Yoshida, Fumiya Kadoriku and Mitsuo Kitamura : Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line, PLoS ONE, Vol.11, No.4, e0154167, 2016.
欧文冊子 ● Kazuyoshi Kitaoka, Shiyori Kawata, Tomohiro Yoshida, Fumiya Kadoriku and Mitsuo Kitamura : Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line, PLoS ONE, Vol.11, No.4, e0154167, 2016.

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