| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 北岡 和義 ([徳島大学.教養教育院])
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| 2. | (英) Kawata Shiyori (日) 川田 知代 (読) かわた しより
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| ○学籍番号 (推奨): | □ | ****
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| 3. | (英) Yoshida Tomohiro (日) 田 朋広 (読) よしだ ともひろ
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Kadoriku Fumiya (日) 角陸 文哉 (読) かどりく ふみや
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 北村 光夫 ([徳島大学.技術支援部])
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| ○題名 (必須): | □ | (英) Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices. In the last several decades, some evidence has shown an association between ELF-MF exposure and depression and/or anxiety in epidemiological and animal studies. The mechanism underlying ELF-MF-induced depression is considered to involve adrenal steroidogenesis, which is triggered by ELF-MF exposure. However, how ELF-MFs stimulate adrenal steroidogenesis is controversial. In the current study, we investigated the effect of ELF-MF exposure on the mouse adrenal cortex-derived Y-1 cell line and the human adrenal cortex-derived H295R cell line to clarify whether the ELF-MF stimulates adrenal steroidogenesis directly. ELF-MF exposure was found to significantly stimulate adrenal steroidogenesis (p < 0.01-0.05) and the expression of adrenal steroid synthetic enzymes (p < 0.05) in Y-1 cells, but the effect was weak in H295R cells. Y-1 cells exposed to an ELF-MF showed significant decreases in phosphodiesterase activity (p < 0.05) and intracellular Ca2+ concentration (p < 0.01) and significant increases in intracellular cyclic adenosine monophosphate (cAMP) concentration (p < 0.001-0.05) and cAMP response element-binding protein phosphorylation (p < 0.05). The increase in cAMP was not inhibited by treatment with NF449, an inhibitor of the Gs alpha subunit of G protein. Our results suggest that ELF-MF exposure stimulates adrenal steroidogenesis via an increase in intracellular cAMP caused by the inhibition of phosphodiesterase activity in Y-1 cells. The same mechanism may trigger the increase in adrenal steroid secretion in mice observed in our previous study. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | e0154167 e0154167
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 21日 (平成 28年 4月 21日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0154167 (→Scopusで検索)
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| ○PMID (任意): | □ | 27100201 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000374898500159
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| ○Scopus (任意): | 1. | 2-s2.0-84964653269
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| ○機関リポジトリ : | □ | 112306
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0154167 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4839720 (日)
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