| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fukushi Isato (日) (読)
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| 2. | (英) Takeda Kotaro (日) (読)
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| 3. | (英) Yokota Shigefumi (日) (読)
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| 4. | (英) Hasebe Yohei (日) (読)
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| 5. | 佐藤 裕 ([徳島大学.大学院社会産業理工学研究部.社会総合科学域.人間科学系.心理学分野]/[徳島大学.総合科学部.社会総合科学科.心身健康コース])
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| 6. | (英) Pokorski Mieczyslaw (日) (読)
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| 7. | (英) Horiuchi Jouji (日) (読)
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| 8. | (英) Okada Yasumasa (日) (読)
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| ○題名 (必須): | □ | (英) Effects of arundic acid, an astrocytic modulator, on the cerebral and respiratory functions in severe hypoxia (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles in information processing in various brain functions. We investigated the hypothesis that astrocytic activation is necessary to maintain the cerebral function and ventilation in hypoxia, by examining the responses of EEG and ventilation to severe hypoxia before and after administration of a modulator of astrocytic function, arundic acid, in unanesthetized mice. Ventilatory parameters were measured by whole body plethysmography. When hypoxic ventilatory depression occurred, gamma frequency band of EEG was suppressed. Arundic acid further suppressed ventilation, and the EEG power was suppressed in a dose-dependent manner. Arundic acid also suppressed hypoxia-induced c-Fos expression in the hypothalamus. We conclude that severe hypoxia suppresses the cerebral function which could reduce the stimulus to the brainstem resulting in ventilatory depression. Astrocytic activation in hypoxia may counteract both cerebral and ventilatory suppression. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Respiratory Physiology & Neurobiology ([Elsevier Science])
(pISSN: 1569-9048, eISSN: 1878-1519)
| ○ISSN (任意): | □ | 1878-1519
ISSN: 1569-9048
(pISSN: 1569-9048, eISSN: 1878-1519) Title: Respiratory physiology & neurobiologyTitle(ISO): Respir Physiol NeurobiolPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 226
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 24 29
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 初日 (平成 28年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.resp.2015.11.011 (→Scopusで検索)
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| ○PMID (任意): | □ | 26592145 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S1569-9048(15)30084-7 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.resp.2015.11.011 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE (日)
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| 4. | (英) KeywordList.Keyword: Arundic acid (日)
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| 5. | (英) KeywordList.Keyword: EEG (日)
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| 6. | (英) KeywordList.Keyword: Glia (日)
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| 7. | (英) KeywordList.Keyword: Hypothalamus (日)
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| 8. | (英) KeywordList.Keyword: Hypoxic ventilatory depression (日)
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| 9. | (英) KeywordList.Keyword: Respiratory control (日)
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