『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=311206EID:311206, Map:0, LastModified:2018年11月29日(木) 11:56:23, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[日野出 大輔], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.Fournier-Larente Jade
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[継承]
2.Azelmat Jabrane
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[継承]
3.吉岡 昌美
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4.日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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[継承]
5.Grenier Daniel
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[継承]
題名 (必須): (英) The Daiokanzoto (TJ-84) Kampo formulation reduces virulence factor gene expression in Porphyromonas gingivalis and possesses anti-inflammatory and anti-protease activities  (日)    [継承]
副題 (任意):
要約 (任意): (英) Kampo formulations used in Japan to treat a wide variety of diseases and to promote health are composed of mixtures of crude extracts from the roots, bark, leaves, and rhizomes of a number of herbs. The present study was aimed at identifying the beneficial biological properties of Daiokanzoto (TJ-84), a Kampo formulation composed of crude extracts of Rhubarb rhizomes and Glycyrrhiza roots, with a view to using it as a potential treatment for periodontal disease. Daiokanzoto dose-dependently inhibited the expression of major Porphyromonas gingivalis virulence factors involved in host colonization and tissue destruction. More specifically, Daiokanzoto reduced the expression of the fimA, hagA, rgpA, and rgpB genes, as determined by quantitative real-time PCR. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to evaluate the anti-inflammatory properties of Daiokanzoto. Daiokanzoto attenuated the P. gingivalis-mediated activation of the NF-κB signaling pathway. It also reduced the secretion of pro-inflammatory cytokines (IL-6 and CXCL8) by lipopolysaccharide-stimulated oral epithelial cells and gingival fibroblasts. Lastly, Daiokanzoto, dose-dependently inhibited the catalytic activity of matrix metalloproteinases (-1 and -9). In conclusion, the present study provided evidence that Daiokanzoto shows potential for treating and/or preventing periodontal disease. The ability of this Kampo formulation to act on both bacterial pathogens and the host inflammatory response, the two etiological components of periodontal disease, is of high therapeutic interest.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS ONE
Publisher: Public Library of Science
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 11 [継承]
(必須): 2 [継承]
(必須): e0148860 e0148860 [継承]
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年月日 (必須): 西暦 2016年 2月 9日 (平成 28年 2月 9日) [継承]
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DOI (任意): 10.1371/journal.pone.0148860    (→Scopusで検索) [継承]
PMID (任意): 26859747    (→Scopusで検索) [継承]
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機関リポジトリ : 112304 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0148860  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC4747585  (日)    [継承]

標準的な表示

和文冊子 ● Jade Fournier-Larente, Jabrane Azelmat, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : The Daiokanzoto (TJ-84) Kampo formulation reduces virulence factor gene expression in Porphyromonas gingivalis and possesses anti-inflammatory and anti-protease activities, PLoS ONE, Vol.11, No.2, e0148860, 2016.
欧文冊子 ● Jade Fournier-Larente, Jabrane Azelmat, Masami Yoshioka, Daisuke Hinode and Daniel Grenier : The Daiokanzoto (TJ-84) Kampo formulation reduces virulence factor gene expression in Porphyromonas gingivalis and possesses anti-inflammatory and anti-protease activities, PLoS ONE, Vol.11, No.2, e0148860, 2016.

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