| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Miwa, Y (日) (読)
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| 2. | (英) Hamamoto H (日) (読)
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| 3. | 石田 竜弘 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物動態制御学]/[徳島大学.大学院医歯薬学研究部.薬学域.連携研究部門(薬学域).寄附講座系(薬学域).がん細胞と代謝学]/[徳島大学.大学産業院])
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| ○題名 (必須): | □ | (英) Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid (日)
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| ○要約 (任意): | □ | (英) Poor transdermal penetration of active pharmaceutical ingredients (APIs) impairs both bioavailability and therapeutic benefits and is a major challenge in the development of transdermal drug delivery systems. Here, we transformed a poorly water-soluble drug, etodolac, into an ionic liquid in order to improve its hydrophobicity, hydrophilicity and skin permeability. The ionic liquid was prepared by mixing etodolac with lidocaine (1:1, mol/mol). Both the free drug and the transformed ionic liquid were characterized by differential scanning colorimetry (DSC), infrared spectroscopy (IR), and saturation concentration measurements. In addition, in vitro skin-permeation testing was carried out via an ionic liquid-containing patch (Etoreat patch). The lidocaine and etodolac in ionic liquid form led to a relatively lower melting point than either lidocaine or etodolac alone, and this improved the lipophilicity/hydrophilicity of etodolac. In vitro skin-permeation testing demonstrated that the Etoreat patch significantly increased the skin permeation of etodolac (9.3-fold) compared with an etodolac alone patch, although an Etoreat patch did not increase the skin permeation of lidocaine, which was consistent with the results when using a lidocaine alone patch. Lidocaine appeared to self-sacrificially improve the skin permeation of etodolac via its transformation into an ionic liquid. The data suggest that ionic liquids composed of approved drugs may substantially expand the formulation preparation method to meet the challenges of drugs which are characterized by poor rates of transdermal absorption. (日)
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| ○誌名 (必須): | □ | European Journal of Pharmaceutics and Biopharmaceutics (Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik)
(pISSN: 0939-6411, eISSN: 1873-3441)
| ○ISSN (任意): | □ | 1873-3441
ISSN: 0939-6411
(pISSN: 0939-6411, eISSN: 1873-3441) Title: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.VTitle(ISO): Eur J Pharm BiopharmPublisher: Elsevier B.V. (NLM Catalog)
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| ○巻 (必須): | □ | 102
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 92 100
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 初日 (平成 28年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ejpb.2016.03.003 (→Scopusで検索)
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| ○PMID (任意): | □ | 26945484 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.ejpb.2016.03.003 (日)
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| 2. | (英) Article.ELocationID: S0939-6411(16)30069-8 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: Etodolac (日)
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| 6. | (英) KeywordList.Keyword: Ionic liquid (日)
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| 7. | (英) KeywordList.Keyword: Poorly water soluble drug (日)
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| 8. | (英) KeywordList.Keyword: Skin permeability (日)
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| 9. | (英) KeywordList.Keyword: Topical delivery (日)
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