| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 水野 大
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| ○学籍番号 (推奨): |
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| 2. | (英) Kimoto Takashi (日) (読)
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| 3. | (英) Sakai Satoko (日) (読)
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| ○貢献度 (任意): |
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| 4. | 高橋 悦久 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | (英) Kim Hyejin (日) (読)
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| 6. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Induction of systemic and mucosal immunity and maintenance of its memory against influenza A virus by nasal vaccination using a new mucosal adjuvant SF-10 derived from pulmonary surfactant in young cynomolgus monkeys (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Induction of systemic and mucosal immunity and maintenance of its memory was investigated in 12 young male cynomolgus monkeys after intranasal instillation of flu vaccine using a new mucosal adjuvant SF-10 derived from pulmonary surfactant constituents. Split-product of influenza virus A/California/7/2009(H1N1)pdm hemagglutinin vaccine (HAv) at 15μg with or without SF-10 and the adjuvant alone were instilled intranasally three times every 2 weeks. SF-10-adjuvanted HAv (SF-10-HAv) elicited significantly higher HAv-specific IgG and hemagglutinin inhibition (HI) titers in serum and HAv-specific secretory IgA and its neutralizing activities in nasal washes compared with HAv antigen and SF-10 alone. Significant cross-neutralizing activities of nasal washes after the third vaccination to several other H1N1 and H3N2 strains were observed. HI titers in serum and neutralizing activities in nasal washes reached peak levels at 6 weeks after initial vaccination, then gradually decreased after 10 weeks and returned to the baseline levels at 36 weeks. A single intranasal revaccination of SF-10-HAv at 36 weeks rapidly and significantly increased both immunity in serum and nasal washes compared with naïve monkeys. Revaccination by one or two doses achieved almost maximal immunity at 2 or 4 weeks after instillation. Statistically significant adverse effects (e.g., body weight loss, elevated body temperature, nasal discharge, change in peripheral blood leukocyte and platelet counts) were not observed for 2 weeks after vaccination of SF-10-HAv, HAv or SF-10 and also during the experimental period. These results in young monkey model suggest the potential of clinical use SF-10 for intranasal flu vaccine. (日)
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| ○キーワード (推奨): | 1. | (英) mucosal adjuvant (日) (読)
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| 2. | (英) nasal vaccination (日) (読)
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| 3. | (英) influenza (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Vaccine (The Edward Jenner Society/The International Society for Vaccines/日本ワクチン学会)
(pISSN: 0264-410X, eISSN: 1873-2518)
| ○ISSN (任意): | □ | 1873-2518
ISSN: 0264-410X
(pISSN: 0264-410X, eISSN: 1873-2518) Title: VaccineTitle(ISO): VaccinePublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 34
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| ○号 (必須): | □ | 16
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| ○頁 (必須): | □ | 1881 1888
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 2月 21日 (平成 28年 2月 21日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.vaccine.2016.02.061 (→Scopusで検索)
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| ○PMID (任意): | □ | 26954466 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000374198500005
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| ○Scopus (任意): | □ | 2-s2.0-84961053795
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.vaccine.2016.02.061 (日)
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| 2. | (英) Article.ELocationID: S0264-410X(16)00256-5 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Cross-neutralization (日)
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| 5. | (英) KeywordList.Keyword: Cynomolgus monkey (日)
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| 6. | (英) KeywordList.Keyword: Mucosal adjuvant (日)
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| 7. | (英) KeywordList.Keyword: Nasal influenza vaccination (日)
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| 8. | (英) KeywordList.Keyword: Pulmonary surfactant (日)
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| 9. | (英) KeywordList.Keyword: Revaccination (日)
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