| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Oh SJ (日) (読)
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| 2. | (英) Ahn S (日) (読)
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| 3. | (英) Jin YH (日) (読)
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| 4. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 5. | (英) Kim JH (日) (読)
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| 6. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 7. | (英) Chung DH (日) (読)
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| ○題名 (必須): | □ | (英) Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells. (日)
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| ○要約 (任意): | □ | (英) Invariant natural killer T cells are a distinct subset of T cells that exert Janus-like functions. Moreover, Notch signaling is known to have critical roles in the development and functions of T cells. However, it is not known whether Notch signaling contributes to the development or functions of invariant natural killer T cells. Here, we found that CD4-specific gene ablation of Notch 1 and Notch 2 (N1N2(-/-)) increased the number of invariant natural killer T cells in the thymus but decreased them in the liver. N1N2(-/-) mice showed impaired thymic maturation of invariant natural killer T cells from the NK1.1(-)CD44(+) to the NK1.1(+)CD44(+) stage, resulting in accumulation of NK1.1(-)CD44(+) invariant natural killer T cells in the thymus. Upon activation, hepatic invariant natural killer T cells from N1N2(-/-) mice produced lower cytokine levels and increased apoptosis versus wild-type invariant natural killer T cells. Furthermore, Notch 1/Notch 2-deficient, but not wild type, invariant natural killer T cells failed to promote antibody-induced arthritis in CD1d(-/-) mice. Unlike N1N2(-/-) mice, RBP-j(lox) (/) (lox) CD4-Cre mice showed similar percentages and numbers of thymic invariant natural killer T cells to wild-type mice but had defects in their homeostasis, maturation, and cytokine production in the liver. Taken together, our data indicate distinct effects of Notch signaling on invariant natural killer T cells in the thymus and liver, which are at least partly independent of RBP-j in the thymus. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Leukocyte Biology (Reticuloendothelial Society/Society for Leukocyte Biology/[Federation of American Societies for Experimental Biology])
(pISSN: 0741-5400, eISSN: 1938-3673)
| ○ISSN (任意): | □ | 1938-3673
ISSN: 0741-5400
(pISSN: 0741-5400, eISSN: 1938-3673) Title: Journal of leukocyte biologyTitle(ISO): J Leukoc BiolSupplier: Society for Leukocyte BiologyPublisher: Oxford University Press (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 98
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 781 789
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 11月 初日 (平成 27年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1189/jlb.1A0914-459RR (→Scopusで検索)
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| ○PMID (任意): | □ | 26188077 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000364911700010
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| ○Scopus (任意): | □ | 2-s2.0-84946011357
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1189/jlb.1A0914-459RR (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: RBP-j (日)
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| 4. | (英) KeywordList.Keyword: arthritis (日)
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| 5. | (英) KeywordList.Keyword: cytokines (日)
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