| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Mori Yoko (日) (読)
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| 2. | (英) Yoshino Yuta (日) (読)
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| 3. | (英) Ochi Shinichiro (日) (読)
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| 4. | (英) Yamazaki Kiyohiro (日) (読)
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| 5. | (英) Kawabe Kentaro (日) (読)
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| 6. | (英) Abe Masao (日) (読)
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| 7. | (英) Kitano Tomoji (日) (読)
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| 8. | (英) Ozaki Yuki (日) (読)
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| 9. | (英) Yoshida Taku (日) (読)
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| 10. | 沼田 周助 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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| 11. | (英) Mori Takaaki (日) (読)
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| 12. | 伊賀 淳一
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| 13. | (英) Kuroda Norio (日) (読)
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| 14. | 大森 哲郎
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| 15. | 上野 修一
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| ○題名 (必須): | □ | (英) TREM2 mRNA Expression in Leukocytes Is Increased in Alzheimer's Disease and Schizophrenia. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) TREM2 and TYROBP are causal genes for Nasu-Hakola disease (NHD), a rare autosomal recessive disease characterized by bone lesions and early-onset progressive dementia. TREM2 forms a receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages and dendritic cells, and the functional polymorphism of TREM2 is reported to be associated with neurodegenerative disorders such as Alzheimer's disease (AD). The objective of this study was to reveal the involvement of TYROBP and TREM2 in the pathophysiology of AD and schizophrenia. We investigated the mRNA expression level of the 2 genes in leukocytes of 26 patients with AD and 24 with schizophrenia in comparison with age-matched controls. Moreover, we performed gene association analysis between these 2 genes and schizophrenia. No differences were found in TYROBP mRNA expression in patients with AD and schizophrenia; however, TREM2 mRNA expression was increased in patients with AD and schizophrenia compared with controls (P < 0.001). There were no genetic associations of either gene with schizophrenia in Japanese patients. TREM2 expression in leukocytes is elevated not only in AD but also in schizophrenia. Inflammatory processes involving TREM2 may occur in schizophrenia, as observed in neurocognitive disorders such as AD. TREM2 expression in leukocytes may be a novel biomarker for neurological and psychiatric disorders. (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Aged, 80 and over (日) (読)
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| 3. | (英) Alzheimer Disease (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Leukocytes (日) (読)
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| 7. | (英) Lipodystrophy (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Membrane Glycoproteins (日) (読)
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| 10. | (英) Osteochondrodysplasias (日) (読)
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| 11. | (英) Polymorphism, Single Nucleotide (日) (読)
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| 12. | (英) RNA, Messenger (日) (読)
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| 13. | (英) Receptors, Immunologic (日) (読)
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| 14. | (英) Schizophrenia (日) (読)
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| 15. | (英) Subacute Sclerosing Panencephalitis (日) (読)
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| 16. | (英) Up-Regulation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 10
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | e0136835 e0136835
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 9月 2日 (平成 27年 9月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0136835 (→Scopusで検索)
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| ○PMID (任意): | □ | 26332043 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000360613800076
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| ○Scopus (任意): | □ | 2-s2.0-84947465878
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0136835 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC4557831 (日)
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