『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨): 教育 [継承]
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Watanabe T (日) (読)
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2. (英) Mitsuhashi M (日) (読)
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3. (英) Sagawa M (日) (読)
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4. (英) Ri M (日) (読)
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5. (英) Suzuki K (日) (読)
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6.安倍 正博
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7. (英) Ohmachi K (日) (読)
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8. (英) Nakagawa Y (日) (読)
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9.中村 信元
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10. (英) Iida S (日) (読)
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11. (英) Kizaki M (日) (読)
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題名 (必須): (英) Lipopolysaccharide-Induced CXCL10 mRNA Level and Six Stimulant-mRNA Combinations in Whole Blood: Novel Biomarkers for Bortezomib Responses Obtained from a Prospective Multicenter Trial for Patients with Multiple Myeloma  (日)    [継承]
副題 (任意):
要約 (任意): (英) To identify predictive biomarkers for clinical responses to bortezomib treatment, 0.06 mL of each whole blood without any cell separation procedures was stimulated ex vivo using five agents, and eight mRNAs were quantified. In six centers, heparinized peripheral blood was prospectively obtained from 80 previously treated or untreated, symptomatic multiple myeloma (MM) patients with measurable levels of M-proteins. The blood sample was procured prior to treatment as well as 2-3 days and 1-3 weeks after the first dose of bortezomib, which was intravenously administered biweekly or weekly, during the first cycle. Six stimulant-mRNA combinations; that is, lipopolysaccharide (LPS)-granulocyte-macrophage colony-stimulating factor (GM-CSF), LPS-CXCL chemokine 10 (CXCL10), LPS-CCL chemokine 4 (CCL4), phytohemagglutinin-CCL4, zymosan A (ZA)-GMCSF and ZA-CCL4 showed significantly higher induction in the complete and very good partial response group than in the stable and progressive disease group, as determined by both parametric (t-test) and non-parametric (unpaired Mann-Whitney test) tests. Moreover, LPS-induced CXCL10 mRNA expression was significantly suppressed 2-3 days after the first dose of bortezomib in all patients, as determined by both parametric (t-test) and non-parametric (paired Wilcoxon test) tests, whereas the complete and very good partial response group showed sustained suppression 1-3 weeks after the first dose. Thus, pretreatment LPS-CXCL10 mRNA and/or the six combinations may serve as potential biomarkers for the response to bortezomib treatment in MM patients.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 10 [継承]
(必須): 6 [継承]
(必須): e0128662 e0128662 [継承]
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年月日 (必須): 西暦 2015年 6月 26日 (平成 27年 6月 26日) [継承]
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DOI (任意): 10.1371/journal.pone.0128662    (→Scopusで検索) [継承]
PMID (任意): 26115406    (→Scopusで検索) [継承]
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WOS (任意): 000358147500016 [継承]
Scopus (任意): 2-s2.0-84938631804 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0128662  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC4482752  (日)    [継承]

標準的な表示

和文冊子 ● T Watanabe, M Mitsuhashi, M Sagawa, M Ri, K Suzuki, Masahiro Abe, K Ohmachi, Y Nakagawa, Shingen Nakamura, S Iida and M Kizaki : Lipopolysaccharide-Induced CXCL10 mRNA Level and Six Stimulant-mRNA Combinations in Whole Blood: Novel Biomarkers for Bortezomib Responses Obtained from a Prospective Multicenter Trial for Patients with Multiple Myeloma, PLoS ONE, Vol.10, No.6, e0128662, 2015.
欧文冊子 ● T Watanabe, M Mitsuhashi, M Sagawa, M Ri, K Suzuki, Masahiro Abe, K Ohmachi, Y Nakagawa, Shingen Nakamura, S Iida and M Kizaki : Lipopolysaccharide-Induced CXCL10 mRNA Level and Six Stimulant-mRNA Combinations in Whole Blood: Novel Biomarkers for Bortezomib Responses Obtained from a Prospective Multicenter Trial for Patients with Multiple Myeloma, PLoS ONE, Vol.10, No.6, e0128662, 2015.

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