| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): | □ | 研究
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hamada Yoshimasa (日) (読)
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| 2. | (英) Bando Tetsuya (日) (読)
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| 3. | (英) Nakamura Taro (日) (読)
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| 4. | 石丸 善康 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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| 5. | 三戸 太郎 ([徳島大学.バイオイノベーション研究所]/[徳島大学.生物資源産業学部.生物資源産業学科.生物生産システム講座])
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| 6. | 野地 澄晴 ([徳島大学])
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| 7. | (英) Tomioka Kenji (日) (読)
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| 8. | 大内 淑代
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| ○題名 (必須): | □ | (英) Regenerated leg segment patterns are regulated epigenetically by histone H3K27 methylation in the cricket Gryllus bimaculatus (日)
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| ○要約 (任意): | □ | (英) Hemimetabolous insects such as the cricket Gryllus bimaculatus regenerate lost tissue parts using blastemal cells, a population of dedifferentiated proliferating cells. The expression of several factors that control epigenetic modification is upregulated in the blastema compared with differentiated tissue, suggesting that epigenetic changes in gene expression might control the differentiation status of blastema cells during regeneration. To clarify the molecular basis of epigenetic regulation during regeneration, we focused on the function of the Gryllus Enhancer of zeste [Gb'E(z)] and Ubiquitously transcribed tetratricopeptide repeat gene on the X chromosome (Gb'Utx) homologues, which regulate methylation and demethylation of histone H3 lysine 27 (H3K27), respectively. Methylated histone H3K27 in the regenerating leg was diminished by Gb'E(z)(RNAi) and was increased by Gb'Utx(RNAi). Regenerated Gb'E(z)(RNAi) cricket legs exhibited extra leg segment formation between the tibia and tarsus, and regenerated Gb'Utx(RNAi) cricket legs showed leg joint formation defects in the tarsus. In the Gb'E(z)(RNAi) regenerating leg, the Gb'dac expression domain expanded in the tarsus. By contrast, in the Gb'Utx(RNAi) regenerating leg, Gb'Egfr expression in the middle of the tarsus was diminished. These results suggest that regulation of the histone H3K27 methylation state is involved in the repatterning process during leg regeneration among cricket species via the epigenetic regulation of leg patterning gene expression. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Development ([The Company of Biologists Limited])
(pISSN: 0950-1991, eISSN: 1477-9129)
| ○ISSN (任意): | □ | 1477-9129
ISSN: 0950-1991
(pISSN: 0950-1991, eISSN: 1477-9129) Title: Development (Cambridge, England)Title(ISO): DevelopmentPublisher: Company of Biologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 142
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| ○号 (必須): | □ | 17
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| ○頁 (必須): | □ | 2916 2927
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 9月 1日 (平成 27年 9月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1242/dev.122598 (→Scopusで検索)
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| ○PMID (任意): | □ | 26253405 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000360763300007
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| ○Scopus (任意): | □ | 2-s2.0-84940734372
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1242/dev.122598 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Epigenetics (日)
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| 4. | (英) KeywordList.Keyword: Gryllus bimaculatus (日)
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| 5. | (英) KeywordList.Keyword: Histone H3K27 (日)
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| 6. | (英) KeywordList.Keyword: Polycomb (日)
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| 7. | (英) KeywordList.Keyword: Regeneration (日)
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