| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Bando S (日) (読)
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| 2. | 福田 大受
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| 3. | 添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 4. | (英) Nishimoto S (日) (読)
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| 5. | (英) Uematsu E (日) (読)
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| 6. | 松浦 朋美 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.循環器内科])
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| 7. | 伊勢 孝之 ([徳島大学.病院.診療科.内科.循環器内科])
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| 8. | 飛梅 威
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| 9. | 山口 浩司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.循環器内科])
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| 10. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])
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| 11. | 岩瀬 俊
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| 12. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| 13. | 若槻 哲三 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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| 14. | 島袋 充生
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| 15. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| ○題名 (必須): | □ | (英) Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis. (日)
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| ○要約 (任意): | □ | (英) ObjectivesThe promotion of adipose tissue inflammation by lifestyle-related diseases such as obesity and diabetes accelerates atherogenesis; however, the underlying mechanisms remain incompletely understood. Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome contributes to chronic inflammation in adipose tissue. Here, we investigated the link between NLRP3 expression in subcutaneous adipose tissue (SAT) and the severity of coronary atherosclerosis.Methods and resultsSAT was obtained from 72 patients who underwent heart device implantation and coronary angiography. Expression of NLRP3 inflammasome-related molecules (NLRP3, IL-1 and IL-18) in SAT were evaluated by quantitative RT-PCR. Laboratory markers related to lifestyle-related diseases were measured. Patients with obesity, dyslipidemia (P < 0.05, respectively), diabetes or hyperuricemia (P < 0.01, respectively) had significantly higher expression of NLRP3. Multivariate analysis demonstrated that body mass index and serum level of uric acid were predictors of NLRP3 expression in SAT. The expression of NLRP3 in SAT correlated negatively with serum adiponectin level (r = 0.23, P < 0.05). Patients with coronary artery disease showed higher NLRP3 expression than patients without significant stenosis (P < 0.01). Furthermore, the expression of NLRP3 in SAT correlated positively with the severity of coronary atherosclerosis as determined by Gensini score (r = 0.47, P < 0.0001) or SYNTAX score (r = 0.55, P < 0.0001). Multiple regression analysis revealed that the expression of NLRP3 in SAT remains as an independent predictors for the severity of coronary atherosclerosis.ConclusionsThe expression of NLRP3 in SAT, which is affected by lifestyle-related diseases, is associated with the severity of coronary atherosclerosis. Our results suggest that NLRP3 inflammasome in SAT may have a role in atherogenesis. (日)
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| ○キーワード (推奨): | 1. | (英) Atherosclerosis (日) (読)
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| 2. | (英) Adipose tissue (日) (読)
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| 3. | (英) Inflammation (日) (読)
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| 4. | (英) NLRP3 inflammasome (日) (読)
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| 5. | (英) Lifestyle-related disease (日) (読)
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| ○発行所 (推奨): | □ | Elsevier Science B.V.
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| ○誌名 (必須): | □ | Atherosclerosis (European Atherosclerosis Society)
(pISSN: 0021-9150, eISSN: 1879-1484)
| ○ISSN (任意): | □ | 1879-1484
ISSN: 0021-9150
(pISSN: 0021-9150, eISSN: 1879-1484) Title: AtherosclerosisTitle(ISO): AtherosclerosisPublisher: Elsevier Ireland Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 242
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 407 414
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 10月 初日 (平成 27年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.atherosclerosis.2015.07.043 (→Scopusで検索)
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| ○PMID (任意): | □ | 26282945 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0021-9150(15)30063-0 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.atherosclerosis.2015.07.043 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: JOURNAL ARTICLE (日)
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| 4. | (英) KeywordList.Keyword: Adipose tissue (日)
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| 5. | (英) KeywordList.Keyword: Atherosclerosis (日)
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| 6. | (英) KeywordList.Keyword: Inflammation (日)
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| 7. | (英) KeywordList.Keyword: Lifestyle-related disease (日)
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| 8. | (英) KeywordList.Keyword: NLRP3 inflammasome (日)
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