『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=298714EID:298714, Map:0, LastModified:2016年8月30日(火) 19:01:20, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Salim HM (日) (読)
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2.福田 大受 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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3. (英) Higashikuni Y (日) (読)
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4. (英) Tanaka K (日) (読)
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[継承]
5. (英) Hirata Y (日) (読)
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6.八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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7.添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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8.島袋 充生
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9.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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[継承]
題名 (必須): (英) Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Background; The dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE-/-) mice and examined its effects on endothelial function. Methods and Results; Lina (10 mg/kg/day) was administered orally to ApoE-/- mice for 20 weeks. Lina reduced atherogenesis without the alteration of metabolic parameters including blood glucose level compared with the control (P<0.05). Results of immunohistochemistry and quantitative RT-PCR demonstrated that Lina significantly decreased inflammatory molecule expression and macrophage infiltration in atherosclerotic aorta. Lina administration to ApoE-/- mice for 9 weeks ameliorated endothelium-dependent vasodilation compared with non-treated mice. Plasma active glucagon-like peptide-1 (GLP-1) level was significantly higher in the treated group (P<0.05). Exendin-4 (Ex-4), a GLP-1 analogue, ameliorated endothelium-dependent vasodilation impaired by palmitic acid (PA) in wild-type mouse aortic segments. Ex-4 promoted phosphorylation of eNOSSer1177 and Akt which are abrogated by PA in human umbilical vein endothelial cells. In addition, Lina administration to ApoE-/- mice decreased oxidative stress as determined by urinary 8-OHdG secretion and NADPH oxidase subunit expression in the abdominal aorta.Conclusion; Lina inhibited atherogenesis in non-diabetic ApoE-/- mice. Amelioration of endothelial dysfunction associated with the reduction of oxidative stress by GLP-1 contributes to the atheroprotective effects of Lina.  (日)    [継承]
キーワード (推奨): 1. (英) DPP-4 inhibitor (日) (読) [継承]
2. (英) linagliptin (日) (読) [継承]
3. (英) GLP-1 (日) (読) [継承]
4. (英) endothelial function (日) (読) [継承]
5. (英) inflammation (日) (読) [継承]
6. (英) oxidative stress (日) (読) [継承]
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): Vascular Pharmacology ([Elsevier])
(pISSN: 1537-1891, eISSN: 1879-3649)

ISSN (任意): 1879-3649
ISSN: 1537-1891 (pISSN: 1537-1891, eISSN: 1879-3649)
Title: Vascular pharmacology
Title(ISO): Vascul Pharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2016年 4月 初日 (平成 28年 4月 初日) [継承]
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DOI (任意): 10.1016/j.vph.2015.08.011    (→Scopusで検索) [継承]
PMID (任意): 26277250    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.vph.2015.08.011  (日)    [継承]
2.(英) Article.ELocationID: S1537-1891(15)00197-4  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: DPP-4 inhibitor  (日)    [継承]
6.(英) KeywordList.Keyword: Endothelial function  (日)    [継承]
7.(英) KeywordList.Keyword: GLP-1  (日)    [継承]
8.(英) KeywordList.Keyword: Inflammation  (日)    [継承]
9.(英) KeywordList.Keyword: Linagliptin  (日)    [継承]
10.(英) KeywordList.Keyword: Oxidative stress  (日)    [継承]

標準的な表示

和文冊子 ● HM Salim, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata : Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice., Vascular Pharmacology, Vol.79, 16-23, 2016.
欧文冊子 ● HM Salim, Daiju Fukuda, Y Higashikuni, K Tanaka, Y Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro and Masataka Sata : Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice., Vascular Pharmacology, Vol.79, 16-23, 2016.

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