| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Salim HM (日) (読)
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| 2. | 福田 大受
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| 3. | (英) Higashikuni Y (日) (読)
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| 4. | (英) Tanaka K (日) (読)
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| 5. | (英) Hirata Y (日) (読)
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| 6. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])
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| 7. | 添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 8. | 島袋 充生
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| 9. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| ○題名 (必須): | □ | (英) Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice. (日)
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| ○要約 (任意): | □ | (英) Background; The dipeptidyl peptidase-4 (DPP-4) inhibitors have vasoprotective effects. This study investigated whether a recently approved DPP-4 inhibitor, linagliptin (Lina), suppresses atherogenesis in non-diabetic apolipoprotein-E deficient (ApoE-/-) mice and examined its effects on endothelial function. Methods and Results; Lina (10 mg/kg/day) was administered orally to ApoE-/- mice for 20 weeks. Lina reduced atherogenesis without the alteration of metabolic parameters including blood glucose level compared with the control (P<0.05). Results of immunohistochemistry and quantitative RT-PCR demonstrated that Lina significantly decreased inflammatory molecule expression and macrophage infiltration in atherosclerotic aorta. Lina administration to ApoE-/- mice for 9 weeks ameliorated endothelium-dependent vasodilation compared with non-treated mice. Plasma active glucagon-like peptide-1 (GLP-1) level was significantly higher in the treated group (P<0.05). Exendin-4 (Ex-4), a GLP-1 analogue, ameliorated endothelium-dependent vasodilation impaired by palmitic acid (PA) in wild-type mouse aortic segments. Ex-4 promoted phosphorylation of eNOSSer1177 and Akt which are abrogated by PA in human umbilical vein endothelial cells. In addition, Lina administration to ApoE-/- mice decreased oxidative stress as determined by urinary 8-OHdG secretion and NADPH oxidase subunit expression in the abdominal aorta.Conclusion; Lina inhibited atherogenesis in non-diabetic ApoE-/- mice. Amelioration of endothelial dysfunction associated with the reduction of oxidative stress by GLP-1 contributes to the atheroprotective effects of Lina. (日)
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| ○キーワード (推奨): | 1. | (英) DPP-4 inhibitor (日) (読)
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| 2. | (英) linagliptin (日) (読)
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| 3. | (英) GLP-1 (日) (読)
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| 4. | (英) endothelial function (日) (読)
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| 5. | (英) inflammation (日) (読)
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| 6. | (英) oxidative stress (日) (読)
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| ○発行所 (推奨): | □ | Elsevier Science B.V.
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| ○誌名 (必須): | □ | Vascular Pharmacology ([Elsevier])
(pISSN: 1537-1891, eISSN: 1879-3649)
| ○ISSN (任意): | □ | 1879-3649
ISSN: 1537-1891
(pISSN: 1537-1891, eISSN: 1879-3649) Title: Vascular pharmacologyTitle(ISO): Vascul PharmacolPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 79
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 16 23
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 4月 初日 (平成 28年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.vph.2015.08.011 (→Scopusで検索)
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| ○PMID (任意): | □ | 26277250 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.vph.2015.08.011 (日)
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| 2. | (英) Article.ELocationID: S1537-1891(15)00197-4 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: DPP-4 inhibitor (日)
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| 6. | (英) KeywordList.Keyword: Endothelial function (日)
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| 7. | (英) KeywordList.Keyword: GLP-1 (日)
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| 8. | (英) KeywordList.Keyword: Inflammation (日)
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| 9. | (英) KeywordList.Keyword: Linagliptin (日)
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| 10. | (英) KeywordList.Keyword: Oxidative stress (日)
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