| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Omoto Katsuhiro (日) (読)
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| 2. | (英) Maruhama K (日) (読)
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| 3. | (英) Terayama R (日) (読)
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| 4. | (英) Yamamoto Yumiko (日) (読)
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| 5. | (英) Matsushita Osam (日) (読)
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| 6. | (英) Sugimoto Tomosada (日) (読)
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| 7. | (英) Oguma Keiji (日) (読)
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| 8. | 松香 芳三 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])
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| ○題名 (必須): | □ | (英) Cross-excitation in peripheral sensory ganglia is associated with pain transmission (日)
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| ○要約 (任意): | □ | (英) Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Toxins (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(eISSN: 2072-6651)
| ○ISSN (任意): | □ | 2072-6651
ISSN: 2072-6651
(eISSN: 2072-6651) Title: ToxinsTitle(ISO): Toxins (Basel)Publisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 2906 2917
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| ○年月日 (必須): | □ | 西暦 2015年 8月 4日 (平成 27年 8月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/toxins7082906 (→Scopusで検索)
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| ○PMID (任意): | □ | 26248078 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000360202700014
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| ○Scopus (任意): | □ | 2-s2.0-84940830023
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| ○機関リポジトリ : | □ | 111969
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3390/toxins7082906 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC4549732 (日)
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| 5. | (英) KeywordList.Keyword: botulinum toxin (日)
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| 6. | (英) KeywordList.Keyword: dorsal root ganglion (日)
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| 7. | (英) KeywordList.Keyword: mechanical allodynia (日)
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| 8. | (英) KeywordList.Keyword: transmitter release (日)
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