『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=296209EID:296209, Map:0, LastModified:2015年7月8日(水) 11:45:53, Operator:[森根 裕二], Avail:TRUE, Censor:0, Owner:[森根 裕二], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (紀要その他) [継承]
言語 (必須): 英語 [継承]
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共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Enkhbold Chinbold (日) (読)
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2. (英) Utsunomiya Tohru (日) (読)
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3.森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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4.居村 暁
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5.池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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6.荒川 悠佑
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7.金本 真美
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8.岩橋 衆一
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9.齋藤 裕 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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10. (英) Ishikawa Daichi (日) (読)
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11.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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題名 (必須): (英) Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) FBXW7 acts as a tumor suppressor gene by targeting several oncogenic regulators of proliferation, growth and apoptosis for proteasomal degradation. However, the significance of this protein is not yet well understood in intrahepatic cholangiocarcinoma (IHCC). In this study, we aimed to investigate the correlation between FBXW7 expression and clinicopathological variables in IHCC patients. Thirty-one patients with IHCC who underwent hepatic resection were enrolled. FBXW7 expression in tumor tissue was determined by immunohistochemistry and patients were divided into two groups, the FBXW7 high expression group (n = 11) and the FBXW7 low expression group (n = 20). We then compared clinicopathological variables including prognosis between the high and low expression groups in tumor tissue. FBXW7 expression was significantly correlated with staging (P = 0.006), and tended to correlate with lymph node metastasis. The FBXW7 low expression group had significantly poorer prognosis compared with the FBXW7 high expression group (P = 0.020); 3-year survival rates were 29.4% and 72.7%, respectively. Furthermore, the disease-free survival rate in the FBXW7 low expression group was significantly worse than in the FBXW7 high expression group (P = 0.022). On multivariate analysis, intrahepatic metastasis (P = 0.006) was a significant independent prognostic factor for disease-free survival, and FBXW7 low expression tended to be an independent prognostic factor for both overall (P = 0.067) and disease-free survival (P = 0.083). Our results confirmed that low expression of FBXW7 in IHCC correlates with tumor progression and poor prognosis in IHCC.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Hepatology Research (日本肝臓学会)
(pISSN: 1386-6346, eISSN: 1872-034X)

ISSN (任意): 1386-6346
ISSN: 1386-6346 (pISSN: 1386-6346, eISSN: 1872-034X)
Title: Hepatology research : the official journal of the Japan Society of Hepatology
Title(ISO): Hepatol Res
Supplier: Japan Society of Hepatology
Publisher: Wiley Publishing
 (NLM Catalog  (医中誌Web  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 44 [継承]
(必須): 14 [継承]
(必須): E346 52 [継承]
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年月日 (必須): 西暦 2014年 3月 18日 (平成 26年 3月 18日) [継承]
URL (任意):
DOI (任意): 10.1111/hepr.12314    (→Scopusで検索) [継承]
PMID (任意): 24552289    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1111/hepr.12314  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: FBXW7  (日)    [継承]
4.(英) KeywordList.Keyword: clinicopathological variables  (日)    [継承]
5.(英) KeywordList.Keyword: intrahepatic cholangiocarcinoma  (日)    [継承]

標準的な表示

和文冊子 ● Chinbold Enkhbold, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa and Mitsuo Shimada : Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma., Hepatology Research, Vol.44, No.14, E346-52, 2014.
欧文冊子 ● Chinbold Enkhbold, Tohru Utsunomiya, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yusuke Arakawa, Mami Kanamoto, Shuichi Iwahashi, Yu Saitou, Daichi Ishikawa and Mitsuo Shimada : Loss of FBXW7 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma., Hepatology Research, Vol.44, No.14, E346-52, 2014.

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