| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ishikawa Daichi (日) (読)
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| 2. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 3. | (英) Utsunomiya Tohru (日) (読)
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| 4. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 5. | 居村 暁
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| 6. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 7. | 荒川 悠佑
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| 8. | 金本 真美
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| 9. | 岩橋 衆一
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| 10. | 齋藤 裕 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 11. | (英) Yamada Shinichiro (日) (読)
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| 12. | 三宅 秀則
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| ○題名 (必須): | □ | (英) Effect of Twist and Bmi1 on intraductal papillary mucinous neoplasm of the pancreas. (日)
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| ○要約 (任意): | □ | (英) Intraductal papillary mucinous neoplasm (IPMN) is a well-established entity among pancreatic neoplasms that ranges from low-grade dysplasia to invasive carcinoma. Epithelial-mesenchymal transition (EMT) contributes to tumor progression in various cancers. Moreover, Notch signaling is one of the important upstream effectors of EMT promotion. Currently, it is unclear whether EMT causes pathological progression of IPMN. We evaluated the expression of EMT-promoting transcription factors Twist and B cell-specific Moloney murine leukemia virus insertion site 1 (Bmi1) in IPMN. Patients who underwent resections at our institute and its affiliated hospital were enrolled in this study (n = 35). Protein expression of EMT markers Twist, Bmi1, Jagged1, and E-cadherin in resected specimens was investigated by immunohistochemistry. Expression of these proteins was compared with the clinicopathological factors and patient survival. Positive expression of Twist and Bmi1 was observed in 40.0% and 42.9% of IPMNs, respectively. Twist and Bmi1 expression was significantly higher in IPMNs with high-grade dysplasia (P < 0.05) and invasive carcinoma (P < 0.05) than that in IPMNs with low-grade dysplasia. High expression of Twist was correlated with Jagged1 expression and inversely correlated with expression of E-cadherin (P = 0.06 and P < 0.05, respectively). In survival analyses, the recurrence rate was significantly higher in the group that showed simultaneous high expression of Twist and Bmi1 (P < 0.05). Expression of Twist and Bmi1 is associated with aggressiveness and poor prognoses of IPMN through EMT promotion that might be induced by Notch signaling. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Gastroenterology and Hepatology ([Blackwell Publishing Ltd])
(pISSN: 0815-9319, eISSN: 1440-1746)
| ○ISSN (任意): | □ | 1440-1746
ISSN: 0815-9319
(pISSN: 0815-9319, eISSN: 1440-1746) Title: Journal of gastroenterology and hepatologyTitle(ISO): J Gastroenterol HepatolSupplier: Journal of Gastroenterology and Hepatology FoundationPublisher: Blackwell (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 29
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| ○号 (必須): | □ | 12
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| ○頁 (必須): | □ | 2032 2037
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 12月 初日 (平成 26年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/jgh.12652 (→Scopusで検索)
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| ○PMID (任意): | □ | 24909638 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/jgh.12652 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Bmi1 (日)
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| 4. | (英) KeywordList.Keyword: Twist (日)
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| 5. | (英) KeywordList.Keyword: cancers: biology (日)
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| 6. | (英) KeywordList.Keyword: diagnosis and therapy (日)
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| 7. | (英) KeywordList.Keyword: epithelial-mesenchymal transition (日)
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| 8. | (英) KeywordList.Keyword: pancreatic neoplasms: biology and therapy (日)
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