| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yamada Shinichiro (日) (読)
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| 2. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 3. | (英) Utsunomiya Tohru (日) (読)
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| 4. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 5. | 齋藤 裕 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 6. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 7. | 居村 暁
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| 8. | 森 大樹 ([徳島大学.病院.診療科.外科.小児外科・小児内視鏡外科])
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| 9. | 荒川 悠佑
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| 10. | 金本 真美
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| 11. | 岩橋 衆一
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| ○題名 (必須): | □ | (英) Trophic effect of adipose tissue-derived stem cells on porcine islet cells. (日)
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| ○要約 (任意): | □ | (英) Adipose tissue-derived stem cells (ADSCs), which are widely known as multipotent progenitor cells, release several cytokines that support cell survival and repair. The aim of this study was to investigate whether ADSC-secreted molecules could induce a trophic effect in pancreatic islet culture conditions in vitro. We cocultured porcine islet cells with ADSCs using a transwell system for 48 h and evaluated the viability of islet cells. We also determined the concentration levels of cytokines and insulin in the supernatant of the culture medium. We used anti-vascular endothelial growth factor (VEGF) and anti-interleukin (IL)-6 receptor antibodies to investigate the effect of VEGF and IL-6 on islet cells. ADSCs improved the viability of islet cells in the absence of cell-cell contact (P < 0.05). VEGF and IL-6 levels in the culture medium increased when islet cells were cocultured with ADSCs (P < 0.05). Furthermore, inhibition of VEGF decreased the viability of islet cells (P < 0.05); however, inhibition of IL-6 did not affect islet cell viability. These results suggested that trophic factors, particularly VEGF, secreted by human ADSCs enhanced the survival and function of porcine islet cells. (日)
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| ○キーワード (推奨): | 1. | (英) Adipose Tissue (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Antibodies (日) (読)
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| 4. | (英) Cell Communication (日) (読)
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| 5. | (英) Cell Survival (日) (読)
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| 6. | (英) Cells, Cultured (日) (読)
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| 7. | (英) Coculture Techniques (日) (読)
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| 8. | (英) Culture Media (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Insulin (日) (読)
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| 12. | (英) Interleukin-6 (日) (読)
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| 13. | (英) Islets of Langerhans (日) (読)
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| 14. | (英) Islets of Langerhans Transplantation (日) (読)
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| 15. | (英) Multipotent Stem Cells (日) (読)
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| 16. | (英) Swine (日) (読)
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| 17. | (英) Vascular Endothelial Growth Factor A (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Surgical Research (Association for Academic Surgery (U.S.)/Association of Veterans Administration Surgeons (U.S.))
(pISSN: 0022-4804, eISSN: 1095-8673)
| ○ISSN (任意): | □ | 1095-8673
ISSN: 0022-4804
(pISSN: 0022-4804, eISSN: 1095-8673) Title: The Journal of surgical researchTitle(ISO): J Surg ResPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 187
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 667 672
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2013年 10月 21日 (平成 25年 10月 21日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jss.2013.10.031 (→Scopusで検索)
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| ○PMID (任意): | □ | 24238974 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jss.2013.10.031 (日)
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| 2. | (英) Article.ELocationID: S0022-4804(13)00976-1 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Adipose tissue-derived stem cells (日)
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| 5. | (英) KeywordList.Keyword: IL-6 (日)
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| 6. | (英) KeywordList.Keyword: Islet transplantation (日)
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| 7. | (英) KeywordList.Keyword: VEGF (日)
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