| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Oka Makiko (日) 岡 真紀子 (読) おか まきこ
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 2. | 丹羽 保晴
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| 3. | 馬渡 一諭
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| 4. | (英) Hiasa Yoshikazu (日) (読)
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| 5. | 中屋 豊
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| ○題名 (必須): | □ | (英) A novel peptide of endothelin family, 31 amino-acid length endothelin in patients with acute myocardial infarction. (日)
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| ○要約 (任意): | □ | (英) Human chymase converts big endothelin (ET)-1 to 31-amino acid length ET-1 {ET-1(1-31)} that also possesses a potent vasoconstrictive action. In addition, ET-1(1-31) is an intermediate peptide, which is then readily transformed to mature ET-1 by the neutral endopeptidase 24-11. To investigate the relevance of pathophysiology of ET-1(1-31) in vivo, we have developed specific sandwich-type, enzyme-linked immunosorbent assay to measure the plasma concentration of ET-1(1-31) in healthy volunteers and patients with myocardial infarction. The plasma concentrations of ET-1(1-31) in healthy volunteers were 24.8 ± 5.2 pg/ml (n=11). ET-1(1-31) concentration in plasma was elevated in patients with acute myocardial infarction, and its elevation was several times higher and lasted longer than that of ET-1. In addition, tissue concentration of ET-1(1-31) in the myocardium from a patient with acute myocardial infarction was extremely high (12729.8 ± 2617.7 pg/mg protein). These results suggest that ET-1(1-31) may play some pathological roles in the remodeling, especially in sites where inflammatory cells produced a large amount of proteases, such as myocardial infarction. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
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(医中誌Web)
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(Scopus)
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| ○巻 (必須): | □ | 61
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| ○号 (必須): | □ | 3-4
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| ○頁 (必須): | □ | 298 305
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 0月 初日 (平成 26年 0月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.61.298 (→Scopusで検索)
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| ○PMID (任意): | □ | 25264048 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84907504152
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| ○機関リポジトリ : | □ | 109577
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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