| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | オリウエラ カンポス リタ クリスティーナ
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 玉木 直文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.予防歯学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 向井 理恵 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 福井 誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 三木 かなめ ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.予防歯学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 寺尾 純二
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 伊藤 博夫 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.予防歯学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) (日) In periodontitis, production of reactive oxygen species (ROS) by neutrophils induces oxidative stress and deteriorates surrounding tissues. Antioxidants reduce damage caused by ROS and are used to treat diseases involving oxidative stress. This study summarizes the different effects of resveratrol, quercetin, and N-acetylcysteine (NAC) on human gingival fibroblasts (HGFs) under oxidative stress induced by hydrogen peroxide. Real-time cytotoxicity analyses reveals that resveratrol and quercetin enhanced cell proliferation even under oxidative stress. Of the antioxidants tested, resveratrol is the most effective at inhibiting ROS production. HGFs incubated with resveratrol and quercetin up-regulate the transcription of type I collagen gene after 3 h, but only resveratrol sustained this up-regulation for 24 h. A measurement of the oxygen consumption rate (OCR, mitochondrial respiration) shows that resveratrol generates the highest maximal respiratory capacity, followed by quercetin and NAC. Simultaneous measurement of OCR and the extracellular acidification rate (non-mitochondrial respiration) reveals that resveratrol and quercetin induce an increase in mitochondrial respiration when compared with untreated cells. NAC treatment consumes less oxygen and enhances more non-mitochondrial respiration. In conclusion, resveratrol is the most effective antioxidant in terms of real-time cytotoxicity analysis, reduction of ROS production, and enhancement of type I collagen synthesis and mitochondrial respiration in HGFs.
| [継承] |
| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
| ○ISSN (任意): | □ | 0912-0009
ISSN: 0912-0009
(pISSN: 0912-0009, eISSN: 1880-5086) Title: Journal of clinical biochemistry and nutritionTitle(ISO): J Clin Biochem NutrSupplier: 一般社団法人 日本酸化ストレス学会Publisher: Institute of Applied Biochemistry (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 56
| [継承] |
| ○号 (必須): | □ | 3
| [継承] |
| ○頁 (必須): | □ | 220 227
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2015年 3月 28日 (平成 27年 3月 28日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.3164/jcbn.14-129 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 26060353 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): | □ | 000368758600010
| [継承] |
| ○Scopus (任意): | □ | 2-s2.0-84929618900
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
| [継承] |