| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Watari Eriko (日) (読)
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| 2. | 竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| 3. | (英) Kitamura Tomoyo (日) (読)
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| 4. | (英) Tanaka Terumi (日) (読)
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| 5. | (英) Ohminami Hirokazu (日) (読)
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| 6. | (英) Abuduli Maerjianghan (日) (読)
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| 7. | 原田 永勝
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| 8. | (英) Yamanaka-Okumura Hisami (日) (読)
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| 9. | 山本 浩範
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| 10. | 武田 英二
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| ○題名 (必須): | □ | (英) Fluctuating plasma phosphorus level by changes in dietary phosphorus intake induces endothelial dysfunction. (日)
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| ○要約 (任意): | □ | (英) High serum phosphorus (P) impairs endothelial function by increasing oxidative stress and decreasing nitric oxide production. Serum P levels fluctuate due to circadian rhythms or dietary P intake in healthy people and due to dialysis in end-stage chronic kidney disease patients. Here we examined whether fluctuating plasma P caused by changes in dietary P intake may be involved in endothelial dysfunction, resulting in increased cardiovascular risk. Rats were fed a diet containing 0.6% P for 16 days (control group), or a diet alternating between 0.02% P and 1.2% P (LH group) or between 1.2% P and 0.02% P (HL group) every 2 days; the total amount of P intake among the groups during the feeding period was similar. In the LH and HL groups, endothelial-dependent vasodilation significantly decreased plasma 8-(OH)dG level significantly increased, and the expression of inflammatory factors such as MCP-1 increased in the endothelium as compared with the control group. These data indicate that repetitive fluctuations of plasma P caused by varying dietary P intake can impair endothelial function via increased oxidative stress and inflammatory response. Taken together, these results suggest that habitual fluctuation of dietary P intake might be a cause of cardiovascular disease through endothelial dysfunction, especially in chronic kidney disease patients. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
| ○ISSN (任意): | □ | 0912-0009
ISSN: 0912-0009
(pISSN: 0912-0009, eISSN: 1880-5086) Title: Journal of clinical biochemistry and nutritionTitle(ISO): J Clin Biochem NutrSupplier: 一般社団法人 日本酸化ストレス学会Publisher: Institute of Applied Biochemistry (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 56
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 35 42
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| ○年月日 (必須): | □ | 西暦 2014年 12月 16日 (平成 26年 12月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3164/jcbn.14-96 (→Scopusで検索)
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| ○PMID (任意): | □ | 25678749 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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