| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Haraya Yuki (日) 原矢 佑樹 (読) はらや ゆうき
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| ○学籍番号 (推奨): | □ | ****
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| 2. | (英) Tanaka Kento (日) 田中 健斗 (読) たなか けんと
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| ○学籍番号 (推奨): | □ | ****
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| 3. | (英) Tsuji Kohei (日) 辻 耕平 (読) つじ こうへい
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Asami Yasuo (日) (読)
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| 5. | (英) Izawa Hironori (日) (読)
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| 6. | 重永 章
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| 7. | 大髙 章 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.機能分子合成薬学])
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| 8. | 斎藤 博幸
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| 9. | (英) Kawakami Kohsaku (日) (読)
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| ○題名 (必須): | □ | (英) Molecular Complex Composed of -Cyclodextrin-Grafted Chitosan and pH-Sensitive Amphipathic Peptide for Enhancing Cellular Cholesterol Efflux under Acidic pH (日)
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| ○要約 (任意): | □ | (英) Excess of cholesterol in peripheral cells is known to lead to atherosclerosis. In this study, a molecular complex composed of -cyclodextrin-grafted chitosan (BCC) and cellular cholesterol efflux enhancing peptide (CEEP), synthesized by modifying pH sensitive amphipathic GALA peptide, is introduced with the eventual aim of treating atherosclerosis. BCC has a markedly enhanced ability to induce cholesterol efflux from cell membranes compared to -cyclodextrin, and the BCC-CEEP complex exhibited a 2-fold increase in cellular cholesterol efflux compared to BCC alone under weakly acidic conditions. Isothermal titration calorimetry and fluorescence spectroscopy measurements demonstrated that the random coil structure of CEEP at neutral pH converted to the -helical structure at acidic pH, resulting in a three-order larger binding constant to BCC (K = 3.7 × 10(7) at pH 5.5) compared to that at pH 7.4 (K = 7.9 × 10(4)). Such high-affinity binding of CEEP to BCC at acidic pH leads to the formation of 100-nm-sized aggregate with positive surface charge, which would efficiently interact with cell membranes and induce cholesterol efflux. Since the cholesterol efflux ability of HDL is thought to be impaired under acidic environments in advanced atherosclerotic lesions, the BCC-CEEP complex might serve as a novel nanomaterial for treating atherosclerosis. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Bioconjugate Chemistry ([アメリカ化学会])
(pISSN: 1043-1802, eISSN: 1520-4812)
| ○ISSN (任意): | □ | 1520-4812
ISSN: 1043-1802
(pISSN: 1043-1802, eISSN: 1520-4812) Title: Bioconjugate chemistryTitle(ISO): Bioconjug ChemPublisher: American Chemical Society (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 26
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 572 581
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| ○年月日 (必須): | □ | 西暦 2015年 3月 2日 (平成 27年 3月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1021/acs.bioconjchem.5b00037 (→Scopusで検索)
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| ○PMID (任意): | □ | 25705984 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000351421000024
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| ○Scopus (任意): | □ | 2-s2.0-84924981137
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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