『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○組織 (推奨):
○著者 (必須): 1. (英) Kojima Sunao (日) (読)
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2. (英) Sakamoto Tomohiro (日) (読)
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3. (英) Ogawa Hisao (日) (読)
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4. (英) Kitagawa Akira (日) (読)
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5. (英) Matsui Kunihiko (日) (読)
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6. (英) Shimomura Hideki (日) (読)
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7. (英) Kimura Kazuo (日) (読)
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8. (英) Ogata Yasuhiro (日) (読)
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9. (英) Sakaino Naritsugu (日) (読)
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10. (英) .Multicenter Study for Aggressive Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors Investigators. (日) (読)
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○題名 (必須): □(英) Standard-dose statin therapy provides incremental clinical benefits in normocholesterolemic diabetic patients.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) BACKGROUND: Randomized trials have established statins as an agent for prevention of coronary heart disease (CHD). The purpose of this study was to assess the hypothesis that standard-dose statin therapy has a beneficial effect in normocholesterolemic diabetic patients with CHD.METHODS AND RESULTS: A prospective, randomized, open, blinded-endpoint trial was conducted from 2002 to 2004 at 55 hospitals in Japan to evaluate the effect of statins on subsequent cardiovascular events. A total number of 1,016 CHD patients (301 patients with type 2 diabetes mellitus [DM] and 715 non-DM patients) with serum total cholesterol levels of 180-240 mg/dl were randomly divided into non-statin and statin treatments. Clinical parameters were comparable between DM and non-DM groups. Serum low-density lipoprotein (LDL)-cholesterol levels were equally decreased after statin treatment in the 2 groups. Statin treatment improved prognosis in both the DM and non-DM groups; however, the number needed to treat (NNT) and relative risk reduction (RRR) were remarkable especially in the DM group (NNT=8, RRR=67%) compared with the non-DM group (NNT=30, RRR=24%).CONCLUSIONS: Standard-dose statin therapy provides incremental clinical benefits in DM patients with normal cholesterol levels compared with non-DM patients. The data suggest that DM patients may enjoy the pleiotropic effects of statins, independent of the LDL-cholesterol lowering effects of these agents.  (日)    [継承]
○キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Cholesterol, LDL (日) (読) [継承]
3. (英) Coronary Disease (日) (読) [継承]
4. (英) Diabetes Mellitus, Type 2 (日) (読) [継承]
5. (英) Dose-Response Relationship, Drug (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Hydroxymethylglutaryl-CoA Reductase Inhibitors (日) (読) [継承]
9.日本 (Japan) [継承]
10. (英) Lipids (日) (読) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Middle Aged (日) (読) [継承]
13. (英) Prospective Studies (日) (読) [継承]
14. (英) Retrospective Studies (日) (読) [継承]
15. (英) Risk Factors (日) (読) [継承]
16. (英) Treatment Outcome (日) (読) [継承]
○発行所 (推奨): □社団法人 日本循環器学会 [継承]
○誌名 (必須): □Circulation Journal ([社団法人 日本循環器学会])
(pISSN: 1346-9843, eISSN: 1347-4820)

○ISSN (任意): □1347-4820
ISSN: 1346-9843 (pISSN: 1346-9843, eISSN: 1347-4820)
Title: Circulation journal : official journal of the Japanese Circulation Society
Title(ISO): Circ J
Supplier: 社団法人日本循環器学会
Publisher: Japanese Circulation Society
 (NLM Catalog)   (CiNii NCID)   (医中誌Web)   (J-STAGE)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □74 [継承]
○号 (必須): □4 [継承]
○頁 (必須): □779 785 [継承]
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○年月日 (必須): □西暦 2010年 2月 17日 (平成 22年 2月 17日) [継承]
○URL (任意):
○DOI (任意): □10.1253/circj.CJ-09-0243    (→Scopusで検索) [継承]
○PMID (任意): □20160396    (→Scopusで検索) [継承]
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○Scopus (任意): 1.2-s2.0-77950671314 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Multicenter Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial  (日)    [継承]

標準的な表示

和文冊子 ● Sunao Kojima, Tomohiro Sakamoto, Hisao Ogawa, Akira Kitagawa, Kunihiko Matsui, Hideki Shimomura, Kazuo Kimura, Yasuhiro Ogata, Naritsugu Sakaino and Multicenter Study for Aggressive Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors Investigators. : Standard-dose statin therapy provides incremental clinical benefits in normocholesterolemic diabetic patients., Circulation Journal, 74, 4, 779-785, 2010.
欧文冊子 ● Sunao Kojima, Tomohiro Sakamoto, Hisao Ogawa, Akira Kitagawa, Kunihiko Matsui, Hideki Shimomura, Kazuo Kimura, Yasuhiro Ogata, Naritsugu Sakaino and Multicenter Study for Aggressive Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors Investigators. : Standard-dose statin therapy provides incremental clinical benefits in normocholesterolemic diabetic patients., Circulation Journal, 74, 4, 779-785, 2010.

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