『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=287684)

EID=287684EID:287684, Map:0, LastModified:2020年8月21日(金) 17:38:17, Operator:[山﨑 哲男], Avail:TRUE, Censor:0, Owner:[山﨑 哲男], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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組織 (推奨):
著者 (必須): 1.山﨑 哲男 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品病態生化学])
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2. (英) Arase H (日) (読)
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3. (英) Ono S (日) (読)
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[継承]
4. (英) Ohno H (日) (読)
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[継承]
5. (英) Watanabe H (日) (読)
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6. (英) Saito T (日) (読)
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題名 (必須): (英) A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) T cell selection is thought to be determined through the interaction between TCR and Ag/MHC. However, the contribution of the level of TCR signal to thymic selection remains unclear. To address this issue, we analyzed T cell selection of male Ag (HY)-specific TCR transgenic (HYTg) mice crossed with CD3 zeta-deficient (zeta KO) mice (HYTg/zeta KO), which have impaired signaling through TCR. In male HYTg/zeta KO mice, the number of thymocytes was comparable to that in normal mice, and almost all the peripheral T cells were HY specific, although these positively selected cells were anergic to male Ag. From these observations, the decrease in TCR signaling by CD3 zeta deficiency resulted in both the avoidance of negative selection and the acquisition of positive selection of autoreactive T cells in male HYTg/zeta KO mice. There was a shift of T cell selection from positive to no selection of HY-specific T cells in female HYTg/zeta KO mice also. Collectively, these findings suggest that the level of TCR signal directly regulates T cell selection; furthermore, the findings have integrated the models of T cell selection into a concept based on the quantity of TCR signal.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD8 (日) (読) [継承]
3. (英) Autoantigens (日) (読) [継承]
4. (英) Cell Differentiation (日) (読) [継承]
5. (英) Clonal Anergy (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) H-Y Antigen (日) (読) [継承]
8. (英) Lymphocyte Activation (日) (読) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Membrane Proteins (日) (読) [継承]
11. (英) Mice (日) (読) [継承]
12. (英) Mice, Inbred C57BL (日) (読) [継承]
13. (英) Mice, Transgenic (日) (読) [継承]
14. (英) Receptors, Antigen, T-Cell (日) (読) [継承]
15. (英) Signal Transduction (日) (読) [継承]
16. (英) Spleen (日) (読) [継承]
17. (英) T-Lymphocytes (日) (読) [継承]
18. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 158 [継承]
(必須): 4 [継承]
(必須): 1634 1640 [継承]
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年月日 (必須): 西暦 1997年 2月 15日 (平成 9年 2月 15日) [継承]
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PMID (任意): 9029099    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuo Yamazaki, H Arase, S Ono, H Ohno, H Watanabe and T Saito : A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice., The Journal of Immunology, Vol.158, No.4, 1634-1640, 1997.
欧文冊子 ● Tetsuo Yamazaki, H Arase, S Ono, H Ohno, H Watanabe and T Saito : A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice., The Journal of Immunology, Vol.158, No.4, 1634-1640, 1997.

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