| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): | □ | 研究
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| ○著者 (必須): | 1. | (英) Taguchi K (日) (読)
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| 2. | 奥村 仙示
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| 3. | (英) Mizuno A (日) (読)
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| 4. | (英) Nakamura T (日) (読)
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| 5. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 6. | 土井 俊夫
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| 7. | (英) Takeda E (日) (読)
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| ○題名 (必須): | □ | (英) Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis (日)
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| ○要約 (任意): | □ | (英) Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patients with LC were divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 61
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| ○号 (必須): | □ | 1.2
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| ○頁 (必須): | □ | 180 189
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| ○年月日 (必須): | □ | 西暦 2014年 0月 初日 (平成 26年 0月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.61.180 (→Scopusで検索)
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| ○PMID (任意): | □ | 24705764 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-84897951186
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| ○機関リポジトリ : | □ | 109552
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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