『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=284663EID:284663, Map:0, LastModified:2014年12月4日(木) 15:40:37, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[青田 桂子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.青田 桂子 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.東 雅之
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学籍番号 (推奨):
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題名 (必須): (英) Targeting TNF- suppresses the production of MMP-9 in human salivary gland cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Tumour necrosis factor- (TNF-) is a pleiotropic cytokine that plays an essential role in inflammation and apoptosis. Our previous study suggested that TNF--induced activation of matrix metalloproteinase-9 (MMP-9) resulted in the destruction of acinar tissue in the salivary glands of patients with Sjögren's syndrome (SS) via disruption of the acinar cell-basement membrane. Recently, a wide array of biological agents has been designed to inhibit TNF, including etanercept and adalimumab. In this study, we demonstrate the suppressive effect of anti-TNF agents on TNF--induced MMP-9 production in NS-AV-AC, an immortalized human salivary gland acinar cell line. NS-AV-AC cells were treated with etanercept or adalimumab after TNF- treatment. MMP-9 production and enzymatic activity were, respectively, visualized by real-time PCR and ELISA assay, and evaluated by gelatin zymography, and apoptosis was evaluated by DNA fragmentation assay. TNF- induced the production of MMP-9 in NS-SV-AC cells. However, this production was greatly inhibited by treatment with etanercept or adalimumab. In addition, TNF--induced DNA fragmentation was prevented by treatment with etanercept or adalimumab. These results may indicate that anti-TNF agents would have therapeutic efficacy for preventing destruction of the acinar structure in the salivary glands of patients with SS.  (日)    [継承]
キーワード (推奨): 1. (英) Acinar Cells (日) (読) [継承]
2. (英) Antibodies, Monoclonal, Humanized (日) (読) [継承]
3. (英) Antirheumatic Agents (日) (読) [継承]
4. (英) Apoptosis (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) DNA Fragmentation (日) (読) [継承]
7. (英) Electrophoresis, Polyacrylamide Gel (日) (読) [継承]
8. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
9. (英) Gene Expression (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Immunoglobulin G (日) (読) [継承]
12. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
13. (英) RNA, Messenger (日) (読) [継承]
14. (英) Real-Time Polymerase Chain Reaction (日) (読) [継承]
15. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
16. (英) Salivary Glands (日) (読) [継承]
17. (英) Sjogren's Syndrome (日) (読) [継承]
18. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Archives of Oral Biology ([Elsevier])
(pISSN: 0003-9969, eISSN: 1879-1506)

ISSN (任意): 1879-1506
ISSN: 0003-9969 (pISSN: 0003-9969, eISSN: 1879-1506)
Title: Archives of oral biology
Title(ISO): Arch Oral Biol
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 58 [継承]
(必須): 12 [継承]
(必須): 1761 1768 [継承]
都市 (任意):
年月日 (必須): 西暦 2013年 9月 21日 (平成 25年 9月 21日) [継承]
URL (任意):
DOI (任意): 10.1016/j.archoralbio.2013.09.004    (→Scopusで検索) [継承]
PMID (任意): 24200302    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1016/j.archoralbio.2013.09.004  (日)    [継承]
2.(英) Article.ELocationID: S0003-9969(13)00294-X  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) KeywordList.Keyword: Matrix metalloproteinase-9  (日)    [継承]
6.(英) KeywordList.Keyword: Salivary gland cells  (日)    [継承]
7.(英) KeywordList.Keyword: Tumour necrosis factor-  (日)    [継承]

標準的な表示

和文冊子 ● Keiko Aota and Masayuki Azuma : Targeting TNF- suppresses the production of MMP-9 in human salivary gland cells., Archives of Oral Biology, Vol.58, No.12, 1761-1768, 2013.
欧文冊子 ● Keiko Aota and Masayuki Azuma : Targeting TNF- suppresses the production of MMP-9 in human salivary gland cells., Archives of Oral Biology, Vol.58, No.12, 1761-1768, 2013.

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