| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 武知 浩和
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| 2. | 馬渡 一諭
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| 3. | 原田 永勝
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| 4. | 中屋 豊
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| 5. | (英) Asakura Megumi (日) (読)
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| 6. | 粟飯原 睦美 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系])
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| 7. | 滝沢 宏光 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学]/[徳島大学.病院.診療科.外科.呼吸器外科])
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| 8. | 後藤 正和 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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| 9. | (英) Nishino Takeshi (日) (読)
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| 10. | (英) Minato Takuya (日) (読)
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| 11. | 古北 由仁
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| 12. | 山本 洋太
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| 13. | (英) Yuasa Yasuhiro (日) (読)
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| 14. | (英) Yamai Hiromichi (日) (読)
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| 15. | 吉田 卓弘
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| 16. | 清家 純一
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| 17. | 丹黒 章
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| ○題名 (必須): | □ | (英) Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model. (日)
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| ○要約 (任意): | □ | (英) Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20 mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO(®)) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model. (日)
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| ○キーワード (推奨): | 1. | (英) glutamine (日) (読)
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| 2. | (英) gastrointestinal toxity (日) (読)
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| 3. | (英) anticancer drug (日) (読)
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| 4. | (英) diamine oxidase (日) (読)
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| 5. | (英) IgA (日) (読)
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| ○発行所 (推奨): | □ | (英) The University of Tokushima Faculty of Medicine (日) (読)
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| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
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| ○巻 (必須): | □ | 61
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 59 64
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 0月 初日 (平成 26年 0月 初日)
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| ○URL (任意): | □ | http://ci.nii.ac.jp/naid/130004822718/
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| ○DOI (任意): | □ | 10.2152/jmi.61.59 (→Scopusで検索)
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| ○PMID (任意): | □ | 24705750 (→Scopusで検索)
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| ○CRID (任意): | □ | 1390001204244693120
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| ○NAID : | □ | 130004822718
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| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-84897937797
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| ○機関リポジトリ : | □ | 109521
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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