| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Koizumi Hidetaka (日) (読)
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| 2. | 森垣 龍馬 ([徳島大学.大学院医歯薬学研究部.医学域.共同研究講座.先端脳機能研究開発]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| 3. | 大北 真哉
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| 4. | 永廣 信治
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| 5. | (英) Nakagawa Masanori (日) (読)
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| 6. | 後藤 惠
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| ○題名 (必須): | □ | (英) Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinsons disease: a potential compensatory role (日)
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| ○要約 (任意): | □ | (英) The opioid peptide receptors consist of three major subclasses, namely, μ, δ, and κ (MOR, DOR, and KOR, respectively). They are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in Parkinson's disease (PD). In this study, we used an immunohistochemistry with tyramide signal amplification (TSA) protocols to determine the distributional patterns of opioid receptors in the striosome-matrix systems of the rat striatum. As a most striking feature of striatal opioid anatomy, MORs are highly enriched in the striosomes and subcallosal streak. We also found that DORs are localized in a mosaic pattern in the dorsal striatum (caudate-putamen), with heightened labeling for DOR in the striosomes relative to the matrix compartment. In the 6-hydroxydopamine-lesioned rat model of PD, lesions of the nigrostriatal pathways caused a significant reduction of striatal labeling for both the MOR and DOR in the striosomes, but not in the matrix compartment. Our results suggest that the activities of the striosome and matrix compartments are differentially regulated by the opioid signals involving the MORs and DORs, and that the striosomes may be more responsive to opioid peptides (e.g., enkephalin) than the matrix compartment. Based on a model in which the striosome compartment regulates the striatal activity, we propose a potent compensatory role of striosomal opioid signaling under the conditions of the striatal dopamine depletion that occurs in PD. (日)
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| ○誌名 (必須): | □ | Frontiers in Cellular Neuroscience (Frontiers Research Foundation)
(eISSN: 1662-5102)
| ○ISSN (任意): | □ | 1662-5102
ISSN: 1662-5102
(eISSN: 1662-5102) Title: Frontiers in cellular neuroscienceTitle(ISO): Front Cell NeurosciPublisher: Frontiers Media SA (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 74 74
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| ○年月日 (必須): | □ | 西暦 2013年 5月 17日 (平成 25年 5月 17日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3389/fncel.2013.00074 (→Scopusで検索)
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| ○PMID (任意): | □ | 23730270 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000319016100001
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| ○Scopus (任意): | □ | 2-s2.0-84877285159
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3389/fncel.2013.00074 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC3656348 (日)
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| 4. | (英) KeywordList.Keyword: Parkinson's disease (日)
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| 5. | (英) KeywordList.Keyword: dopamine (日)
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| 6. | (英) KeywordList.Keyword: opioid receptors (日)
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| 7. | (英) KeywordList.Keyword: striatum (日)
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| 8. | (英) KeywordList.Keyword: striosomes (日)
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