| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 西川 裕美子
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| 2. | 西嶋 仁
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| 3. | (英) Matsumoto Minoru (日) (読)
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| 4. | 森本 純子 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 5. | 廣田 史子
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| 6. | (英) Takahashi Satoru (日) (読)
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| 7. | (英) Luche Hervé (日) (読)
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| 8. | (英) Fehring Hans Joerg (日) (読)
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| 9. | 毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 10. | 松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○題名 (必須): | □ | (英) Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program. (日)
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| ○要約 (任意): | □ | (英) Understanding the cellular dynamics of Aire-expressing lineage(s) among medullary thymic epithelial cells (AEL-mTECs) is essential for gaining insight into the roles of Aire in establishment of self-tolerance. In this study, we monitored the maturation program of AEL-mTECs by temporal lineage tracing, in which bacterial artificial chromosome transgenic mice expressing tamoxifen-inducible Cre recombinase under control of the Aire regulatory element were crossed with reporter strains. We estimated that the half-life of AEL-mTECs subsequent to Aire expression was ∼7-8 d, which was much longer than that reported previously, owing to the existence of a post-Aire stage. We found that loss of Aire did not alter the overall lifespan of AEL-mTECs, inconsistent with the previous notion that Aire expression in medullary thymic epithelial cells (mTECs) might result in their apoptosis for efficient cross-presentation of self-antigens expressed by AEL-mTECs. In contrast, Aire was required for the full maturation program of AEL-mTECs, as exemplified by the lack of physiological downregulation of CD80 during the post-Aire stage in Aire-deficient mice, thus accounting for the abnormally increased CD80(high) mTECs seen in such mice. Of interest, increased CD80(high) mTECs in Aire-deficient mice were not mTEC autonomous and were dependent on cross-talk with thymocytes. These results further support the roles of Aire in the differentiation program of AEL-mTECs. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD80 (日) (読)
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| 3. | (英) Apoptosis (日) (読)
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| 4. | (英) Autoantigens (日) (読)
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| 5. | (英) Cell Differentiation (日) (読)
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| 6. | (英) Cell Lineage (日) (読)
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| 7. | (英) Cells, Cultured (日) (読)
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| 8. | (英) Cross-Priming (日) (読)
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| 9. | (英) Epithelial Cells (日) (読)
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| 10. | (英) Flow Cytometry (日) (読)
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| 11. | (英) Immunohistochemistry (日) (読)
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| 12. | (英) Kinetics (日) (読)
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| 13. | (英) Luminescent Proteins (日) (読)
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| 14. | (英) Mice (日) (読)
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| 15. | (英) Mice, Inbred C57BL (日) (読)
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| 16. | (英) Mice, Knockout (日) (読)
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| 17. | (英) Mice, Transgenic (日) (読)
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| 18. | (英) Thymocytes (日) (読)
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| 19. | (英) Thymus Gland (日) (読)
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| 20. | (英) Time Factors (日) (読)
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| 21. | (英) Transcription Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 1550-6606
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 192
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 2585 2592
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2014年 2月 10日 (平成 26年 2月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.4049/jimmunol.1302786 (→Scopusで検索)
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| ○PMID (任意): | □ | 24516201 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000332702700007
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| ○Scopus (任意): | □ | 2-s2.0-84897508383
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.4049/jimmunol.1302786 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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