『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=274493EID:274493, Map:0, LastModified:2018年3月25日(日) 18:16:18, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[池田 康将], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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著者 (必須): 1.池田 康将 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/[徳島大学.医学部.医学科.病態情報医学講座.薬理学分野]/[徳島大学.医科学教育部.医学専攻.病態情報医学講座]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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2. (英) Ozono Iori (日) 大園 伊織 (読) おおぞの いおり
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学籍番号 (推奨): **** [ユーザ]
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3. (英) Tajima Soichro (日) (読)
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4. (英) Imao Mizuki (日) 今尾 瑞季 (読) いまお みずき
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学籍番号 (推奨): **** [ユーザ]
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5.堀ノ内 裕也
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6.石澤 有紀 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学]/->個人[井澤 有紀])
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7.木平 孝高
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8.宮本 理人
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9.石澤 啓介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床薬理学])
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10.土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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11.玉置 俊晃
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題名 (必須): (英) Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction  (日)    [継承]
副題 (任意):
要約 (任意): (英) Renal fibrosis plays an important role in the onset and progression of chronic kidney diseases (CKD). Although several mechanisms underlying renal fibrosis and candidate drugs for its treatment have been identified, the effect of iron chelator on renal fibrosis remains unclear. In the present study, we examined the effect of an iron chelator, deferoxamine (DFO), on renal fibrosis in mice with surgically induced unilateral ureter obstruction (UUO). Mice were divided into 4 groups: UUO with vehicle, UUO with DFO, sham with vehicle, and sham with DFO. One week after surgery, augmented renal tubulointerstitial fibrosis and the expression of collagen I, III, and IV increased in mice with UUO; these changes were suppressed by DFO treatment. Similarly, UUO-induced macrophage infiltration of renal interstitial tubules was reduced in UUO mice treated with DFO. UUO-induced expression of inflammatory cytokines and extracellular matrix proteins was abrogated by DFO treatment. DFO inhibited the activation of the transforming growth factor-β1 (TGF-β1)-Smad3 pathway in UUO mice. UUO-induced NADPH oxidase activity and p22(phox) expression were attenuated by DFO. In the kidneys of UUO mice, divalent metal transporter 1, ferroportin, and ferritin expression was higher and transferrin receptor expression was lower than in sham-operated mice. Increased renal iron content was observed in UUO mice, which was reduced by DFO treatment. These results suggest that iron reduction by DFO prevents renal tubulointerstitial fibrosis by regulating TGF-β-Smad signaling, oxidative stress, and inflammatory responses.  (日)    [継承]
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誌名 (必須): PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)

ISSN (任意): 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: Public Library of Science
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 9 [継承]
(必須): 2 [継承]
(必須): e89355 e89355 [継承]
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年月日 (必須): 西暦 2014年 2月 19日 (平成 26年 2月 19日) [継承]
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DOI (任意): 10.1371/journal.pone.0089355    (→Scopusで検索) [継承]
PMID (任意): 24586712    (→Scopusで検索) [継承]
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WOS (任意): 000331711900131 [継承]
Scopus (任意): 2-s2.0-84897786390 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1371/journal.pone.0089355  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC3929716  (日)    [継承]

標準的な表示

和文冊子 ● Yasumasa Ikeda, Iori Ozono, Soichro Tajima, Mizuki Imao, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Toshiaki Tamaki : Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction, PLoS ONE, Vol.9, No.2, e89355, 2014.
欧文冊子 ● Yasumasa Ikeda, Iori Ozono, Soichro Tajima, Mizuki Imao, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Toshiaki Tamaki : Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction, PLoS ONE, Vol.9, No.2, e89355, 2014.

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