| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Eskander N. Ramez (日) (読)
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| 2. | (英) Randall M. Leslie (日) (読)
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| 3. | 酒井 紀典 ([徳島大学.病院.中央診療施設等.高度先進整形外科診療部])
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| 4. | (英) Guo Yi (日) (読)
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| 5. | (英) Hoang Bang (日) (読)
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| 6. | (英) Zi Xiaolin (日) (読)
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| ○題名 (必須): | □ | (英) Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) To examine the effects of flavokawain B (FKB), a novel kava chalcone, on the growth of uterine leiomyosarcoma (LMS) cells and investigated its utility in the treatment of uterine LMS. Uterine leiomyosarcoma (SK-LMS-1), endometrial adenocarcinoma (ECC-1) and the non-malignant, human endometrium fibroblast-like (T-HESC) cell lines were cultured and treated with different concentrations of FKB. Cell viability was determined by MTT assays and the IC(50) was estimated. Fluorescent-activated cell sorting (FACS) analysis of apoptosis and cell cycle was performed. Real-time reverse-transcription polymerase chain reaction and western blot analysis were utilized to evaluate differences in the expression of apoptotic markers. FKB preferentially inhibited the growth of SK-LMS-1 and ECC-1 cells compared to T-HESC control cells. FKB significantly increased both early and late apoptosis in SK-LMS-1 and ECC-1 cells relative to control. Cell cycle analysis illustrated an increase in the G2/M fraction in treated cell lines relative to control. Furthermore, FKB induced the expression of pro-apoptotic death receptor 5 (DR5), Bim, and Puma, and decreased expression of an inhibitor of apoptosis, survivin. FKB also acted synergistically when combined with docetaxel and gemcitabine (combination index = 0.260). FKB treatment results in cell cycle arrest and a robust induction of apoptosis in SK-LMS-1 and ECC-1 cell lines. This natural product deserved further investigation as a potential therapeutic agent in the treatment of uterine LMS. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents (日) (読)
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| 2. | (英) Apoptosis (日) (読)
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| 3. | (英) Cell Line, Tumor (日) (読)
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| 4. | (英) Deoxycytidine (日) (読)
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| 5. | (英) Drug Evaluation, Preclinical (日) (読)
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| 6. | (英) Drug Synergism (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Fibroblasts (日) (読)
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| 9. | (英) Flavonoids (日) (読)
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| 10. | (英) G2 Phase Cell Cycle Checkpoints (日) (読)
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| 11. | (英) Gene Expression Regulation, Neoplastic (日) (読)
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| 12. | (英) Humans (日) (読)
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| 13. | (英) Inhibitor of Apoptosis Proteins (日) (読)
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| 14. | (英) Leiomyosarcoma (日) (読)
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| 15. | (英) Phytotherapy (日) (読)
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| 16. | (英) Plant Extracts (日) (読)
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| 17. | (英) Taxoids (日) (読)
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| 18. | (英) Uterine Neoplasms (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Obstetrics and Gynaecology Research (日本産科婦人科学会)
(pISSN: 1341-8076, eISSN: 1447-0756)
| ○ISSN (任意): | □ | 1447-0756
ISSN: 1341-8076
(pISSN: 1341-8076, eISSN: 1447-0756) Title: The journal of obstetrics and gynaecology researchTitle(ISO): J Obstet Gynaecol ResSupplier: Japan Society of Obstetrics and GynecologyPublisher: Blackwell (NLM Catalog)
(医中誌Web)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 38
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 1086 1094
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 4月 30日 (平成 24年 4月 30日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.1447-0756.2011.01841.x (→Scopusで検索)
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| ○PMID (任意): | □ | 22540374 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/j.1447-0756.2011.01841.x (日)
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| 2. | (英) Article.Affiliation: Departments of Obstetrics and Gynecology, University of California Irvine, Orange, CA, USA. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 5. | (英) OtherID: NIHMS343335 (日)
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| 6. | (英) OtherID: PMC3405181 (日)
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