| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tsunematsu Takaaki (日) (読)
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| 2. | (英) Takihara Yoshihiro (日) (読)
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| 3. | 石丸 直澄
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| 4. | (英) Pagano Michele (日) (読)
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| 5. | 高田 隆 ([広島大学])
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| 6. | 工藤 保誠 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| ○題名 (必須): | □ | (英) Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis. (日)
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| ○要約 (任意): | □ | (英) Geminin, an essential factor for DNA replication, directly binds to the licensing factor Cdt1 and inhibits pre-replicative complex formation to prevent re-replication. In G1, geminin levels are controlled by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase complex, which targets geminin for proteasomal degradation to allow pre-replicative complex formation. Conversely, from S to G2, geminin is stabilized due to APC/C ubiquitin ligase complex inhibition, ensuring the inhibition of pre-replicative complex formation. However, mitotic regulation of geminin has hitherto not been described. Here we show that Aurora-A phosphorylates geminin on Thr25 during M phase, and this event induces geminin stabilization by preventing its APC/C ubiquitin ligase complex-mediated degradation during mitosis. In turn, stabilized geminin inhibits SCF(Skp2)-mediated degradation of Cdt1 to ensure pre-replicative complex formation in the ensuing S phase. The Aurora-A-geminin-Cdt1 axis therefore represents a critical regulator of proper DNA replication. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Communications ([Nature Publishing Group])
(eISSN: 2041-1723)
| ○ISSN (任意): | □ | 2041-1723
ISSN: 2041-1723
(eISSN: 2041-1723) Title: Nature communicationsTitle(ISO): Nat CommunPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 4
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| ○号 (必須): |
| ○頁 (必須): |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2013年 0月 初日 (平成 25年 0月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ncomms2859 (→Scopusで検索)
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| ○PMID (任意): | □ | 23695679 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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