| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Lian Gaojian (日) 練 髙建 (読) りあん がおしん
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 3. | 北村 明子
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| 4. | 西田 純
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| 5. | (英) Li Shigen (日) (読)
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| 6. | 岸原 健二
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| 7. | 前川 洋一
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| 8. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice. (日)
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| ○要約 (任意): | □ | (英) The interplay of CD4(+) and CD8(+) T cells targeting autoantigens is responsible for the progression of a number of autoimmune diseases, including type 1 diabetes mellitus (T1D). Understanding the molecular mechanisms that regulate T cell activation is crucial for designing effective therapies for autoimmune diseases. We probed a panel of Abs with T cell-modulating activity and identified a mAb specific for the H chain of CD98 (CD98hc) that was able to suppress T cell proliferation. The anti-CD98hc mAb also inhibited Ag-specific proliferation and the acquisition of effector function by CD4(+) and CD8(+) T cells in vitro and in vivo. Injection of the anti-CD98hc mAb completely prevented the onset of cyclophosphamide-induced diabetes in NOD mice. Treatment of diabetic NOD mice with anti-CD98hc reversed the diabetic state to normal levels, coincident with decreased proliferation of CD4(+) T cells. Furthermore, treatment of diabetic NOD mice with CD98hc small interfering RNA resolved T1D. These data indicate that strategies targeting CD98hc might have clinical application for treating T1D and other T cell-mediated autoimmune diseases. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibodies, Monoclonal (日) (読)
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| 3. | (英) Antigens, CD98 Heavy Chain (日) (読)
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| 4. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 5. | (英) CD8-Positive T-Lymphocytes (日) (読)
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| 6. | (英) Cyclophosphamide (日) (読)
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| 7. | (英) Diabetes Mellitus, Type 1 (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Growth Inhibitors (日) (読)
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| 10. | (英) Mice (日) (読)
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| 11. | (英) Mice, Inbred BALB C (日) (読)
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| 12. | (英) Mice, Inbred C57BL (日) (読)
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| 13. | (英) Mice, Inbred NOD (日) (読)
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| 14. | (英) Mice, SCID (日) (読)
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| 15. | (英) Mice, Transgenic (日) (読)
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| 16. | (英) Rats (日) (読)
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| 17. | (英) Rats, Wistar (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 1550-6606
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 188
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 2227 2234
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2012年 1月 30日 (平成 24年 1月 30日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.4049/jimmunol.1102586 (→Scopusで検索)
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| ○PMID (任意): | □ | 22291182 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. (日)
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| 2. | (英) PublicationType: Journal Article (日)
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| 3. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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