『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=253052EID:253052, Map:0, LastModified:2022年7月25日(月) 16:50:56, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[安友 康二], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1. (英) Xu Mingli (日) (読)
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○学籍番号 (推奨):
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2. (英) Morishima Noriko (日) (読)
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3. (英) Mizoguchi Izuru (日) (読)
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4. (英) Chiba Yukino (日) (読)
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○学籍番号 (推奨):
[継承]
5. (英) Fujita Koji (日) (読)
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[継承]
6. (英) Kuroda Masahiko (日) (読)
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7. (英) Iwakura Yoichiro (日) (読)
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○学籍番号 (推奨):
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8. (英) Cua Daniel J (日) (読)
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○学籍番号 (推奨):
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9.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
○役割 (任意):
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○学籍番号 (推奨):
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10. (英) Mizuguchi Junichiro (日) (読)
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[継承]
11. (英) Yoshimoto Takayuki (日) (読)
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○学籍番号 (推奨):
[継承]
○題名 (必須): □(英) Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) IL-23 plays a critical role in the expansion of highly proinflammatory Th17 cells secreting IL-17 and IL-22. Recently, we demonstrated that Notch signaling drives IL-22 secretion through the aryl hydrocarbon receptor (AHR) and plays a protective role in Con A-induced hepatitis. In this study, we investigated the role of IL-23 in hepatitis using IL-23p19- and IL-17-deficient mice. In WT mice, the injection of Con A induced the upregulation of various cytokines which included IL-23, IL-22, IL-17, IFN- and TNF-. In IL-23p19-deficient mice, exacerbated hepatitis was observed and serum IL-22 and IL-17 levels were greatly reduced, whereas in IL-17-deficient mice, ameliorated hepatitis was observed. The injection of exogenous IL-22 protected p19-deficient mice from hepatitis, whereas the injection of exogenous IL-23 significantly increased the serum levels of not only IL-22 but also IL-17, and less effectively protected against hepatitis in IL-17-dependent and -independent manners. Finally, it was revealed that STAT3, STAT4 and Notch contributed to the production of both cytokines, and that the AHR was important only for IL-22 production in response to Con A and IL-23 in liver mononuclear cells. These results suggest that IL-23 plays a protective role in hepatitis through IL-22 production and also a pathological role via IL-17-dependent and -independent mechanisms.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Concanavalin A (日) (読) [継承]
3. (英) Cytokines (日) (読) [継承]
4. (英) Hepatitis, Animal (日) (読) [継承]
5. (英) Interleukin-17 (日) (読) [継承]
6. (英) Interleukin-23 (日) (読) [継承]
7. (英) Interleukin-23 Subunit p19 (日) (読) [継承]
8. (英) Interleukins (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11.ノックアウトマウス (knockout mice) [継承]
12. (英) Receptors, Aryl Hydrocarbon (日) (読) [継承]
13. (英) Receptors, Notch (日) (読) [継承]
14. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
15. (英) STAT3 Transcription Factor (日) (読) [継承]
16. (英) STAT4 Transcription Factor (日) (読) [継承]
17.シグナル伝達 (signal transduction) [継承]
18. (英) Th17 Cells (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)

○ISSN (任意): □1521-4141
ISSN: 0014-2980 (pISSN: 0014-2980, eISSN: 1521-4141)
Title: European journal of immunology
Title(ISO): Eur J Immunol
Supplier: European Federation of Immunological Societies
Publisher: Wiley
 (NLM Catalog)   (Wiley)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □41 [継承]
○号 (必須): □10 [継承]
○頁 (必須): □2828 2839 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2011年 7月 18日 (平成 23年 7月 18日) [継承]
○URL (任意):
○DOI (任意): □10.1002/eji.201141291    (→Scopusで検索) [継承]
○PMID (任意): □21953641    (→Scopusで検索) [継承]
○CRID (任意):
○WOS (任意): □000296199000006 [継承]
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○備考 (任意): 1.(英)   (日) 著者5.参照不要 確認済み   [継承]
2.(英) Article.ELocationID: 10.1002/eji.201141291  (日)    [継承]
3.(英) Article.Affiliation: Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mingli Xu, Noriko Morishima, Izuru Mizoguchi, Yukino Chiba, Koji Fujita, Masahiko Kuroda, Yoichiro Iwakura, J Daniel Cua, Koji Yasutomo, Junichiro Mizuguchi and Takayuki Yoshimoto : Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production., European Journal of Immunology, Vol.41, No.10, 2828-2839, 2011.
欧文冊子 ● Mingli Xu, Noriko Morishima, Izuru Mizoguchi, Yukino Chiba, Koji Fujita, Masahiko Kuroda, Yoichiro Iwakura, J Daniel Cua, Koji Yasutomo, Junichiro Mizuguchi and Takayuki Yoshimoto : Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production., European Journal of Immunology, Vol.41, No.10, 2828-2839, 2011.

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