| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Batmunkh Rentsenkhand (日) (読)
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| 2. | 西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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| 3. | 青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
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| 4. | 東 桃代 ([徳島大学.病院.中央診療施設等.感染制御部])
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| 5. | (英) Kinoshita Katsuhiro (日) (読)
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| 6. | 岸 潤
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| 7. | (英) Makino Hideki (日) (読)
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| 8. | (英) Kishi Masami (日) (読)
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| 9. | (英) Takezaki Akio (日) (読)
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| 10. | 曽根 三郎
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| ○題名 (必須): | □ | (英) CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized by the proliferation of fibroblasts and increased deposition of the extracellular matrix. The CCN6/WISP-3 is a member of the CCN family of matricellular proteins, which consists of six members that are involved in many vital biological functions. However, the regulation of lung fibroblasts mediated by CCN6 protein has not been fully elucidated. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin β1, leading to the phosphorylation of FAK(Y397). Furthermore, CCN6 showed a weak, but significant, ability to stimulate the expression of fibronectin. CCN6 was highly expressed in the lung tissues of mice treated with bleomycin. Our results suggest that CCN6 plays a role in the fibrogenesis of the lungs mainly by stimulating the growth of lung fibroblasts and is a potential target for the treatment of pulmonary fibrosis. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD29 (日) (読)
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| 3. | (英) CCN Intercellular Signaling Proteins (日) (読)
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| 4. | (英) Cell Proliferation (日) (読)
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| 5. | (英) Extracellular Matrix Proteins (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Fibroblasts (日) (読)
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| 8. | (英) Focal Adhesion Protein-Tyrosine Kinases (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Lung (日) (読)
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| 11. | (英) Mice (日) (読)
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| 12. | (英) Mice, Inbred C57BL (日) (読)
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| 13. | 肺線維症 (pulmonary fibrosis)
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| 14. | シグナル伝達 (signal transduction)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 58
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| ○号 (必須): | □ | 3-4
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| ○頁 (必須): | □ | 188 196
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 8月 初日 (平成 23年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.58.188 (→Scopusで検索)
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| ○PMID (任意): | □ | 21921419 (→Scopusで検索)
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| ○CRID (任意): |
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| ○機関リポジトリ : | □ | 83833
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Respiratory Medicine and Rheumatology, University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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