『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=251417EID:251417, Map:0, LastModified:2017年12月4日(月) 13:59:02, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[居村 暁], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
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組織 (推奨):
著者 (必須): 1. (英) Iwahashi Shuichi (日) (読)
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[継承]
2.石橋 広樹 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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3.宇都宮 徹
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4.森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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5. (英) Ochir Lkhaguva Tovuu (日) (読)
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[継承]
6.花岡 潤
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7.森 大樹 ([徳島大学.病院.診療科.外科.小児外科・小児内視鏡外科])
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8.池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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9.居村 暁 ([徳島大学.病院.中央診療施設等.地域外科診療部])
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10.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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題名 (必須): (英) Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Histone deacetylase (HDAC) is well known to be associated with tumorigenesis through epigenetic regulation, and its inhibitors (HDACIs) induce differentiation and apoptosis of tumor cells. We examined the therapeutic effects of valproic acid (VPA, a HDACI) with a combination of 5-fluorouracil (5-FU) in vitro. A human pancreas cancer cell line (SUIT-2) and a cholangiocarcinoma cell line (HuCCT1) were used. Cell viabilities were evaluated by a cell proliferation assay. We determined the anticancer effects of VPA combined with 5-FU in these cell lines. Pancreas cancer (SUIT-2): No effect of 5-FU (1.0 µM) was observed, but 17% and 30% of proliferation-inhibitory effects were recognized in a dose of 2.5 or 5.0 µM, respectively. Cell viability was only weakly reduced by VPA (0.5 mM). However, in combination of 5-FU (1.0 µM) with VPA (0.5 mM), 19% of inhibitory effect was observed. Cholangiocarcinoma (HuCCT1): 5-FU (1.0 µM) did not suppress the cell viability, but 5-FU (2.5 µM) suppressed by 23%. VPA (0.5 mM) did not suppress the cell viability, while VPA (1.0 mM) weakly decreased it by 11%. Combination of 5-FU (1.0 µM) and VPA (0.5 mM) markedly reduced the cell viability by 30%. VPA augmented the anti-tumor effects of 5-FU in cancer cell lines. Therefore, a combination therapy of 5-FU plus VPA may be a promising therapeutic option for patients with pancreas cancer and cholangiocarcinoma.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Combined Chemotherapy Protocols (日) (読) [継承]
2. (英) Bile Duct Neoplasms (日) (読) [継承]
3. (英) Bile Ducts, Intrahepatic (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Cell Proliferation (日) (読) [継承]
6. (英) Cell Survival (日) (読) [継承]
7. (英) Cholangiocarcinoma (日) (読) [継承]
8. (英) Fluorouracil (日) (読) [継承]
9. (英) Histone Deacetylase Inhibitors (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Pancreatic Neoplasms (日) (読) [継承]
12. (英) Valproic Acid (日) (読) [継承]
13. (英) (日) 欧文論文 (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (CrossRef (Scopus information is found. [need login])
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(必須): 106 109 [継承]
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年月日 (必須): 西暦 2011年 2月 初日 (平成 23年 2月 初日) [継承]
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DOI (任意): 10.2152/jmi.58.106    (→Scopusで検索) [継承]
PMID (任意): 21372494    (→Scopusで検索) [継承]
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機関リポジトリ : 83933 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Digestive Surgery and Transplantation, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Shuichi Iwahashi, Hiroki Ishibashi, Toru Utsunomiya, Yuji Morine, Tovuu Lkhaguva Ochir, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines., The Journal of Medical Investigation : JMI, Vol.58, No.1-2, 106-109, (発行所), (都市), Feb. 2011.
欧文冊子 ● (種別) : Shuichi Iwahashi, Hiroki Ishibashi, Toru Utsunomiya, Yuji Morine, Tovuu Lkhaguva Ochir, Jun Hanaoka, Hiroki Mori, Tetsuya Ikemoto, Satoru Imura and Mitsuo Shimada : Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines., The Journal of Medical Investigation : JMI, Vol.58, No.1-2, 106-109, (発行所), (都市), Feb. 2011.

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