| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 石舟 智恵子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 2. | (英) Maekawa Yoichi (日) (読)
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| 3. | 西田 純
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| 4. | (英) Kitamura Akiko (日) (読)
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| 5. | (英) Kenji Tanigaki (日) (読)
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| 6. | (英) Hideo Yagita (日) (読)
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| 7. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) required for T-cell activation and are classified into several subtypes by phenotypic and functional characteristics. However, it remains unclear if distinct transcription factors control the development of each DC subpopulation. In this report, we demonstrate that Notch signaling controls the development of a novel DC subtype that expresses Thy1 (Thy1(+) DCs). Overstimulation of bone marrow cells with the Notch ligand Delta-like 1 promoted the development of Thy1(+) DCs. Thy1(+) DCs are characterized as CD11c(+) MHC class II(+) NK1.1(-) B220(-) CD8(+) , and are present in the thymus but not in the spleen and lymph nodes. Thymic Thy1(+) DCs are able to capture exogenous proteins and delete CD4(+) CD8(+) T cells. Transplantation experiments demonstrated that CD44(+) CD25(-) and CD44(+) CD25(+) thymocytes can differentiate into Thy1(+) DCs. Recombination signal binding protein for immunoglobulin kappa J region (RBP-J) deficiency in lineage-negative bone marrow cells, but not CD11c(+) cells, disrupted Thy1(+) DC development in the thymus. Our data indicate that Notch signaling controls the development of a novel type of Thy1-expressing DC in the thymus that possibly controls negative selection, and indicates that there may be highly regulated, differential transcriptional control of DC development. Furthermore, our findings suggest that Notch signaling regulates T-cell development not only by intrinsically inducing T-cell lineage-specific gene programs, but also by regulating negative selection through Thy1(+) DCs. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigen Presentation (日) (読)
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| 3. | (英) Antigens, CD11c (日) (読)
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| 4. | (英) Antigens, CD44 (日) (読)
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| 5. | (英) Antigens, Thy-1 (日) (読)
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| 6. | (英) Blotting, Western (日) (読)
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| 7. | (英) Bone Marrow Cells (日) (読)
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| 8. | (英) Cell Differentiation (日) (読)
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| 9. | (英) Dendritic Cells (日) (読)
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| 10. | (英) Flow Cytometry (日) (読)
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| 11. | (英) Immunoglobulin J Recombination Signal Sequence-Binding Protein (日) (読)
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| 12. | (英) Interleukin-2 Receptor alpha Subunit (日) (読)
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| 13. | (英) Lymphocyte Activation (日) (読)
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| 14. | (英) Membrane Proteins (日) (読)
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| 15. | (英) Mice (日) (読)
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| 16. | (英) Mice, Inbred C57BL (日) (読)
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| 17. | (英) Mice, Transgenic (日) (読)
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| 18. | (英) Polymerase Chain Reaction (日) (読)
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| 19. | (英) Receptors, Notch (日) (読)
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| 20. | (英) Signal Transduction (日) (読)
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| 21. | (英) T-Lymphocytes (日) (読)
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| 22. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)
| ○ISSN (任意): | □ | 1521-4141
ISSN: 0014-2980
(pISSN: 0014-2980, eISSN: 1521-4141) Title: European journal of immunologyTitle(ISO): Eur J ImmunolSupplier: European Federation of Immunological SocietiesPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 41
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1309 1320
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2011年 4月 12日 (平成 23年 4月 12日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/eji.201041159 (→Scopusで検索)
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| ○PMID (任意): | □ | 21469122 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000289957100017
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/eji.201041159 (日)
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| 2. | (英) Article.Affiliation: Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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