| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部.創生科学研究部門.環境共生科学分野 (2009年4月1日〜2016年3月31日)
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| ○著者 (必須): | 1. | (英) Nishimura Yumiko (日) (読)
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| 2. | 小山 保夫
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| ○題名 (必須): | □ | (英) Further analysis on lidocaine-induced increase in intracellular Zn2+ concentration: Cytometric model study using FluoZin-3, 5-chloromethylfluorescein, and rat thymocytes (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Lidocaine augmented FluoZin-3 fluorescence of rat thymocytes, suggesting the increase in intracellular Zn2+ concentration. However, the mechanism for lidocaine-induced increase in the intensity of FluoZin-3 fluorescence was not elucidated. In this study, in order to reveal the mechanism, the effects of lidocaine on FluoZin-3 and 5-chloromethylfluorescein (5-CMF) fluorescence were examined under various conditions. 5-CMF fluorescence was used as a parameter for cellular content of nonprotein thiols. The lidocaine-induced augmentation of FluoZin-3 fluorescence was observed under external Ca2+- and/or Zn2+-free conditions, suggesting that lidocaine induced intracellular Zn2+ release. Lidocaine attenuated 5-CMF fluorescence, suggesting the decrease in cellular content of nonprotein thiols. Since some peptides consisting of SH-group have been proposed to store Zn2+, the decrease in nonprotein thiol content by lidocaine reduced the cellular ability to store Zn2+, leading to an increase in intracellular Zn2+ concentration. (日) Lidocaine augmented FluoZin-3 fluorescence of rat thymocytes, suggesting the increase in intracellular Zn2+ concentration. However, the mechanism for lidocaine-induced increase in the intensity of FluoZin-3 fluorescence was not elucidated. In this study, in order to reveal the mechanism, the effects of lidocaine on FluoZin-3 and 5-chloromethylfluorescein (5-CMF) fluorescence were examined under various conditions. 5-CMF fluorescence was used as a parameter for cellular content of nonprotein thiols. The lidocaine-induced augmentation of FluoZin-3 fluorescence was observed under external Ca2+- and/or Zn2+-free conditions, suggesting that lidocaine induced intracellular Zn2+ release. Lidocaine attenuated 5-CMF fluorescence, suggesting the decrease in cellular content of nonprotein thiols. Since some peptides consisting of SH-group have been proposed to store Zn2+, the decrease in nonprotein thiol content by
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| ○キーワード (推奨): | 1. | (英) Lidocaine (日) (読)
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| 2. | (英) Intracellular Zn2+ level (日) (読)
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| 3. | (英) FluoZin-3 (日) (読)
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| ○発行所 (推奨): | □ | 徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部 (2009年4月1日〜2016年3月31日)
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| ○誌名 (必須): | □ | Natural Science Research ([徳島大学.大学院ソシオ・アーツ・アンド・サイエンス研究部])
(pISSN: 0914-6385)
| ○ISSN (任意): | □ | 0914-6385
ISSN: 0914-6385
(pISSN: 0914-6385) Title: 徳島大学総合科学部自然科学研究Supplier: 徳島大学 (Webcat Plus)
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| ○巻 (必須): | □ | 26
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 7 10
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| ○都市 (任意): | □ | 徳島 (Tokushima/[日本国])
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| ○年月日 (必須): | □ | 西暦 2012年 4月 末日 (平成 24年 4月 末日)
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| ○URL (任意): | □ | http://repo.lib.tokushima-u.ac.jp/96861
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| ○CRID (任意): | □ | 1050001337463881984
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| ○NAID : | □ | 110009517148
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| ○機関リポジトリ : | □ | 96861
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