| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sakaki Manabu (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 福森 知治
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 布川 朋也 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学]/[徳島大学.病院.診療科.外科.泌尿器科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Elsamman Essam (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | (英) Shiirevnyamba Avirmed (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 6. | 中逵 弘能
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 金山 博臣
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Clinical significance of Galectin-3 in clear cell renal cell carcinoma. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Overexpression of galectin-3 in a variety of cancer cell lines has been shown to correlate with tumor progression and metastasis. In this study, we investigated the expression of galectin-3 in clear cell renal cell carcinoma (CC-RCC) and evaluated the relationship between galectin-3 expression levels and the clinicopathological features of CC-RCC. Expression of galectin-3 in the kidney cancer cell lines Caki-1, Caki-2, A704, ACHN and KPK-1 were evaluated using western blot analysis, while galectin-3 expression in CC-RCC tissues and normal parenchyma were measured by real-time PCR and immunohistochemistry. We found that galectin-3 was overexpressed in the Caki-1, Caki-2, A704, ACHN and KPK-1 cell lines and that the expression level in CC-RCC was also significantly higher than that in renal parenchyma obtained from the same patient samples (p=0.039). Galectin-3 expression in CC-RCC with distant metastasis was also significantly higher than that in CC-RCC without distant metastasis (p=0.045). In conclusion, we revealed that galectin-3 is highly expressed in CC-RCC, especially in CC-RCC with distant metastasis, suggesting that galectin-3 may serve as a novel target molecule for predicting CC-RCC metastasis. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Carcinoma, Renal Cell (日) (読)
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| 5. | (英) Cell Line, Tumor (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | ガレクチン-3 (galectin-3)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Kidney Neoplasms (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Middle Aged (日) (読)
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| 12. | (英) Neoplasm Metastasis (日) (読)
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| 13. | (英) Prognosis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 57
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 152 157
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2010年 2月 初日 (平成 22年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.57.152 (→Scopusで検索)
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| ○PMID (任意): | □ | 20299755 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 78648
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Urology, Institute of Health Biosciences, University of Tokushima Graduated School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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