『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=233672EID:233672, Map:0, LastModified:2012年10月18日(木) 22:55:29, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[平尾 功治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Adachi Tomohiko (日) (読)
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2.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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3.湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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4.平尾 功治 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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5.高橋 加奈子
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6.向井 佳代
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7.中江 英明
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8.松尾 敬志
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題名 (必須): (英) Caries-related bacteria and cytokines induce CXCL10 in dental pulp.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Marked infiltration of inflammatory cells, such as activated T-cells, is observed in the progression of pulpitis; however, little is known about the mechanism of their recruitment into pulpal lesions. It has been recently demonstrated that CXC chemokine ligand 10 (CXCL10) chemoattracts CXC chemokine receptor 3 (CXCR3)-positive activated T-cells. We therefore examined whether CXCL10 is involved in the pathogenesis of pulpitis. CXCL10 mRNA expression levels in clinically inflamed dental pulp were higher than those in healthy dental pulp. Immunostaining results revealed that CXCL10 was detected in macrophages, endothelial cells, and fibroblasts in inflamed dental pulp, and that CXCR3 expression was observed mainly on T-cells. Moreover, cultured dental pulp fibroblasts produced CXCL10 after stimulation with live caries-related bacteria, peptidoglycans, and pro-inflammatory cytokines. In contrast, heat-killed bacteria did not induce CXCL10 secretion. These findings suggest that CXCL10-CXCR3 may play an important role in the pulpal immune response to caries-related bacterial invasion. Abbreviations: CXCL10, CXC chemokine ligand 10; CXCR3, CXC chemokine receptor 3; IFN, interferon; FBS, fetal bovine serum; LTA, lipoteichoic acid; PGN, peptidoglycan; IL, interleukin; TNF, tumor necrosis factor; PBS, phosphate-buffered saline; ELISA, enzyme-linked immunosorbent assay; CCL, C-C chemokine ligand; TLR, Toll-like receptor; NOD, nucleotide oligomerization domain; HDPF, human dental pulp fibroblasts.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Bacteroides (日) (読) [継承]
3. (英) Chemokine CXCL10 (日) (読) [継承]
4. (英) Dental Caries (日) (読) [継承]
5. (英) Dental Pulp (日) (読) [継承]
6. (英) Fibroblasts (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Immunohistochemistry (日) (読) [継承]
9. (英) Lymphocyte Subsets (日) (読) [継承]
10. (英) Middle Aged (日) (読) [継承]
11. (英) RNA, Messenger (日) (読) [継承]
12. (英) Receptors, CXCR3 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Dental Research ([国際歯科研究学会])
(pISSN: 0022-0345, eISSN: 1544-0591)

ISSN (任意): 0022-0345
ISSN: 0022-0345 (pISSN: 0022-0345, eISSN: 1544-0591)
Title: Journal of dental research
Title(ISO): J. Dent. Res.
Publisher: SAGE Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 12月 初日 (平成 19年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1177/154405910708601215    (→Scopusで検索) [継承]
PMID (任意): 18037659    (→Scopusで検索) [継承]
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WOS (任意): 000251157000014 [継承]
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備考 (任意): 1.(英) Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) PublicationType: Journal Article  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tomohiko Adachi, Tadashi Nakanishi, Hiromichi Yumoto, Kouji Hirao, Kanako Takahashi, Kayo Mukai, Hideaki Nakae and Takashi Matsuo : Caries-related bacteria and cytokines induce CXCL10 in dental pulp., Journal of Dental Research, Vol.86, No.12, 1217-1222, 2007.
欧文冊子 ● Tomohiko Adachi, Tadashi Nakanishi, Hiromichi Yumoto, Kouji Hirao, Kanako Takahashi, Kayo Mukai, Hideaki Nakae and Takashi Matsuo : Caries-related bacteria and cytokines induce CXCL10 in dental pulp., Journal of Dental Research, Vol.86, No.12, 1217-1222, 2007.

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