『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=232707)

EID=232707EID:232707, Map:0, LastModified:2013年7月29日(月) 14:19:27, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患プロテオゲノム研究センター (2008年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.プロテオゲノム研究領域]) [継承]
著者 (必須): 1. (英) Mat Ripen A (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.新田 剛
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学籍番号 (推奨):
[継承]
3. (英) Murata S (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tanaka K (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5.高浜 洋介
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t  (日)    [継承]
副題 (任意):
要約 (任意): (英) Proteasomes are responsible for generating peptides presented by class I MHC molecules of the immune system. β5t, a recently identified proteasome component, is specifically expressed in thymic cortical epithelial cells (cTECs) and plays a pivotal role in generating an immunocompetent repertoire of class I MHC-restricted CD8(+) T cells. Here, we report that β5t is detectable in the thymus as early as E12.5 mouse embryos. We also found that β5t expression in cTECs was detectable in mice deficient for RelB or Rag2, indicating that β5t in cTECs is expressed in the absence of thymic medulla formation or thymocyte development beyond the CD4(-) CD8(-) stage. β5t expression in the embryonic thymus was not detectable in Foxn1-deficient nude mice, although its expression was not reduced in mice deficient for both CCR7 and CCR9, in which fetal thymus colonization by leukocytes is defective. These results indicate that β5t expression in cTECs is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) DNA-Binding Proteins (日) (読) [継承]
5. (英) Epithelial Cells (日) (読) [継承]
6. (英) Forkhead Transcription Factors (日) (読) [継承]
7. (英) Histocompatibility Antigens Class I (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred BALB C (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11. (英) Mice, Nude (日) (読) [継承]
12. (英) Mice, Transgenic (日) (読) [継承]
13. (英) Microscopy, Confocal (日) (読) [継承]
14. (英) Precursor Cells, T-Lymphoid (日) (読) [継承]
15. (英) Proteasome Endopeptidase Complex (日) (読) [継承]
16. (英) Receptors, CCR (日) (読) [継承]
17. (英) Receptors, CCR7 (日) (読) [継承]
18. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
19. (英) Thymus Gland (日) (読) [継承]
20. (英) Transcription Factor RelB (日) (読) [継承]
発行所 (推奨):
誌名 (必須): European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)

ISSN (任意): 1521-4141
ISSN: 0014-2980 (pISSN: 0014-2980, eISSN: 1521-4141)
Title: European journal of immunology
Title(ISO): Eur J Immunol
Supplier: European Federation of Immunological Societies
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 41 [継承]
(必須): 5 [継承]
(必須): 1278 1287 [継承]
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年月日 (必須): 西暦 2011年 4月 14日 (平成 23年 4月 14日) [継承]
URL (任意):
DOI (任意): 10.1002/eji.201041375    (→Scopusで検索) [継承]
PMID (任意): 21469133    (→Scopusで検索) [継承]
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WOS (任意): 000289957100014 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1002/eji.201041375  (日)    [継承]
2.(英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● A Ripen Mat, Takeshi Nitta, S Murata, K Tanaka and Yousuke Takahama : Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t, European Journal of Immunology, Vol.41, No.5, 1278-1287, 2011.
欧文冊子 ● A Ripen Mat, Takeshi Nitta, S Murata, K Tanaka and Yousuke Takahama : Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t, European Journal of Immunology, Vol.41, No.5, 1278-1287, 2011.

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